The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Research Abstract Details 

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The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Abstract Text:

Martijn P Lolkema,Dorus A Mans,Cristel M Snijckers,Mascha van Noort,Moniek van Beest,Emile E Voest,Rachel H Giles,

Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Publishing Authors By Initials

MP Lolkema,DA Mans,CM Snijckers,M van Noort,M van Beest,EE Voest,RH Giles,

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The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 581

Page Numbers: 4571-6

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 31

MONTH: 08

YEAR: 2007

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Information

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LANGUAGE: eng

NlmUniqueID: 155157

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Keywords Mesh Terms:

KEYWORDS: Von Hippel-Lindau Tumor Suppressor Prote

MESH TERMS: metabolism

Chemical & Substance for Abstract: The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. Information

Substance Name: Von Hippel-Lindau Tumor Suppressor Prote

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.

AFFILIATION: Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, rm F02.126, 3584 CX Utrecht, The Netherlands.

Country: Netherlands

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MEDLINETA: FEBS Lett

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