The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals.

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Research Abstract Details 

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The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Abstract Text:

E H Young,N J Wareham,S Farooqi,A Hinney,J Hebebrand,A Scherag,S O'rahilly,I Barroso,M S Sandhu,

BACKGROUND: Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation. METHODS: We assessed the association between the V103I polymorphism in the MC4R gene and obesity in three UK population based cohort studies, totalling 8304 individuals. We also did a meta-analysis of relevant studies, involving 10 975 cases and 18 588 controls, to place our findings in context. FINDING: In an analysis of all studies, individuals carrying the isoleucine allele had an 18% (95% confidence interval 4-30%, P=0.015) lower risk of obesity compared with non-carriers. There was no heterogeneity among studies and no apparent publication bias. INTERPRETATION: This study confirms that the V103I polymorphism protects against human obesity at a population level. As such it provides proof of principle that specific gene variants may, at least in part, explain susceptibility and resistance to common forms of human obesity. A better understanding of the mechanisms underlying this association will help determine whether changes in MC4R activity have therapeutic potential.

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Publishing Authors By Initials

EH Young,NJ Wareham,S Farooqi,A Hinney,J Hebebrand,A Scherag,S O'rahilly,I Barroso,MS Sandhu,

For similar proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, melanocortin: receptor, melanocortin, type 4 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, melanocortin: receptor, melanocortin, type 4 research

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The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of obesity (2005)

VOLUME: 31

Page Numbers: 1437-41

Journal Abbreviation:

ISSN: 0307-0565

DAY: 13

MONTH: 03

YEAR: 2007

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Information

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LANGUAGE: eng

NlmUniqueID: 101256108

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Keywords Mesh Terms:

KEYWORDS: Receptor, Melanocortin, Type 4

MESH TERMS: genetics

Chemical & Substance for Abstract: The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Information

Substance Name: Receptor, Melanocortin, Type 4

Registry Number: 0

Grant and Affiliation Information for The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals.

AFFILIATION: MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK. elizabeth.young@mrc-epid.cam.ac.uk

Country: England

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MEDLINETA: Int J Obes (Lond)

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