The use of the hippocampal slice preparation in the study of Alzheimer's disease.

The use of the hippocampal slice preparation in the study of Alzheimer's disease. Research Abstract Details 

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The use of the hippocampal slice preparation in the study of Alzheimer's disease. Abstract Text:

In the present article we show how studying synaptic mechanisms in hippocampal slice preparations provides information that may be useful in, firstly, the understanding of the aetiology of Alzheimer's disease and, secondly, in the development of novel therapies for dementia. We use several examples, drawn from our own work: (i) The identification of the function of AMPA receptors and NMDA receptors in synaptic transmission and synaptic plasticity. (ii) The discovery of mechanisms that can regulate the activation of NMDA receptors. (iii) The use of transgenic models of Alzheimer's disease. (iv) The identification of a mechanism that can account for the cognitive enhancing effects of the NMDA receptor antagonist memantine. (v) The discovery of a role of glycogen synthase kinase-3beta (tau kinase) in synaptic plasticity.

The use of the hippocampal slice preparation in the study of Alzheimer's disease. Publishing Authors By Initials

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The use of the hippocampal slice preparation in the study of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pharmacology

VOLUME: 585

Page Numbers: 50-9

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 29

MONTH: 02

YEAR: 2008

The use of the hippocampal slice preparation in the study of Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 1254354

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Grant and Affiliation Information for The use of the hippocampal slice preparation in the study of Alzheimer's disease.

AFFILIATION: MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK.

Country: Netherlands

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MEDLINETA: Eur J Pharmacol

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