The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis.

The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Research Abstract Details 

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The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Abstract Text:

BACKGROUND AND DESIGN.--Many investigators have applied immunohistologic analysis to skin biopsy specimens to distinguish cutaneous T-cell lymphoma (CTCL) from benign inflammatory diseases, such as psoriasis and dermatitis, which can clinically mimic early-stage CTCL. We studied the number and distribution of epidermal cells labeled with various monoclonal antibodies in normal skin and in psoriatic, dermatitic, and CTCL lesions by the immunoperoxidase technique. RESULTS.--Extensive staining of keratinocytes (KCs) with HLA-DR was seen in 27 of 41 patients with CTCL, but in only one of 14 patients with psoriasis and zero of 10 patients with dermatitis. CD2+ and CD3+ cells were present in the middle and upper epidermis of CTCL lesions in much greater numbers than in normal, dermatitic, and psoriatic skin. The percent epidermal area covered by CD1+ cells in psoriatic lesions (1.13%) and dermatitic lesions (1.65%) was significantly lower than that found in CTCL lesions (3.60%). CONCLUSION.--Epidermal immunohistologic patterns using anti-CD1, anti-CD2, anti-CD3, and anti-HLA-DR antibodies have the potential to distinguish CTCL from psoriasis and dermatitis in clinically ambiguous cases.

The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Publishing Authors By Initials

For similar neoplasms: neoplasms by site: skin neoplasms research abstracts see: neoplasms: neoplasms by site: skin neoplasms research

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The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 127

Page Numbers: 1503-10

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Oct

YEAR: 1991

The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Keywords Mesh Terms:

KEYWORDS: Skin Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis. Information

Substance Name: HLA-DR Antigens

Registry Number: 0

Grant and Affiliation Information for The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis.

AFFILIATION: Department of Dermatology, Yale University School of Medicine, New Haven, Conn.

Country: UNITED STATES

AGENCY: United States NCI

GRANT: CA 49414

ACRONYM: CA

MEDLINETA: Arch Dermatol

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