The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry.

The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry. Research Abstract Details 

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The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry. Abstract Text:

R Jones,M J Orchard,K Hall,

Derivative UV spectrophotometry is well established for analysing pharmaceutical products containing more than one drug. By contrast, the least-squares method for over-determined systems is rarely used, because it is assumed that measurements at a large number of wavelengths are needed to obtain good results. Both methods have advantages, and their use in combination is useful for analysing polypharmaceuticals. A combination of derivative and least-squares methods was used to analyse tablets containing pseudoephedrine hydrochloride, triprolidine hydrochloride and dextromethorphan hydrobromide. Pseudoephedrine was determined by derivative spectrophotometry. The other drugs were determined by the least-squares method at higher wavelengths where pseudoephedrine does not absorb. Satisfactory precision for the least-squares method was obtained with a manual spectrometer measuring at six wavelengths and calculating the results with a microcomputer.

The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry. Publishing Authors By Initials

R Jones,MJ Orchard,K Hall,

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The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 3

Page Numbers: 335-42

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ISSN: 0731-7085

DAY: 26

MONTH: 07

YEAR: 1985

The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry.

AFFILIATION: Central Analytical Laboratories (Chemical), The Wellcome Foundation Ltd., Temple Hill, Dartford, Kent DA1 5AH, UK.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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