The use of 5-hydroxytryptophol as an alcohol intake marker.

The use of 5-hydroxytryptophol as an alcohol intake marker. Research Abstract Details 

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The use of 5-hydroxytryptophol as an alcohol intake marker. Abstract Text:

5-Hydroxytryptophol (5HTOL) occurs naturally in animals as a metabolite of serotonin. Ethanol interacts with serotonin metabolism to increase the production of 5HTOL at the expense of 5-hydroxyindoleacetic acid (5HIAA). This can be used clinically in the treatment of alcohol dependence to improve the detection of relapse in alcohol drinking, by monitoring daily the urinary 5HTOL/5HIAA ratio. In one experiment the sensitivity of this marker in detecting alcohol drinking the previous day was more than 10-fold greater than measuring urinary ethanol. Genetic polymorphism in alcohol and aldehyde dehydrogenases, which is known to influence the ethanol metabolism, does not confound the clinical use of 5HTOL as a marker. Disulfiram and cyanamide, however, will elevate urinary 5HTOL/5HIAA ratio.

The use of 5-hydroxytryptophol as an alcohol intake marker. Publishing Authors By Initials

For similar human activities: temperance research abstracts see: human activities: temperance research

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The use of 5-hydroxytryptophol as an alcohol intake marker. Journal Published:

PUBLICATION TYPE: Review

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 2

Page Numbers: 497-502

Journal Abbreviation:

ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1994

The use of 5-hydroxytryptophol as an alcohol intake marker. Information

Number of References: 30

LANGUAGE: eng

NlmUniqueID: 8804836

The use of 5-hydroxytryptophol as an alcohol intake marker. Keywords Mesh Terms:

KEYWORDS: Temperance

MESH TERMS: metabolism

Chemical & Substance for Abstract: The use of 5-hydroxytryptophol as an alcohol intake marker. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for The use of 5-hydroxytryptophol as an alcohol intake marker.

AFFILIATION: Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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