The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing.

The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Research Abstract Details 

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The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Abstract Text:

Robert G Gourdie,Gautam S Ghatnekar,Michael O'Quinn,Matthew J Rhett,Ralph J Barker,Ching Zhu,Jane Jourdan,Andrew W Hunter,

Intercellular connectivity mediated by gap junctions (GJs) composed of connexin43 (Cx43) is critical to the function of excitable tissues such as the heart and brain. Disruptions to Cx43 GJ organization are thought to be a factor in cardiac arrhythmias and are also implicated in epilepsy. This article is based on a presentation to the 4th Larry and Horti Fairberg Workshop on Interactive and Integrative Cardiology and summarizes the work of Gourdie and his lab on Cx43 GJs in the heart. Background and perspective of recently published studies on the function of Cx43-interacting protein zonula occludens-(ZO)-1 in determining the organization of GJ plaques are provided. In addition how a peptide containing a PDZ-binding sequence of Cx43, developed as part of the work on cardiac GJ organization is also described, which has led to evidence for novel and unexpected roles for Cx43 in modulating healing following tissue injury.

The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Publishing Authors By Initials

RG Gourdie,GS Ghatnekar,M O'Quinn,MJ Rhett,RJ Barker,C Zhu,J Jourdan,AW Hunter,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1080

Page Numbers: 49-62

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 3

MONTH: Oct

YEAR: 2006

The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Information

Number of References: 70

LANGUAGE: eng

NlmUniqueID: 7506858

The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: physiology

Chemical & Substance for Abstract: The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Information

Substance Name: zonula occludens-1 protein

Registry Number: 0

Grant and Affiliation Information for The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing.

AFFILIATION: Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA. gourdier@musc.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL 56728

ACRONYM: HL

MEDLINETA: Ann N Y Acad Sci

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