The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor.

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Research Abstract Details 

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The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Abstract Text:

A series of the synthetic protein kinase inhibitors known as tyrphostins were examined for their effects on the tyrosine autophosphorylation of the pp140c-trk, nerve growth factor (NGF) receptor. One of the tyrphostins, AG879, inhibited NGF-dependent pp140c-trk tyrosine phosphorylation, but did not affect tyrosine phosphorylation of epidermal growth factor or platelet-derived growth factor receptors. In addition, the tyrosine phosphorylation of the receptor-associated protein pp38 was also attenuated by the tyrphostin. This effect was time- and dose-dependent, although inhibition of pp38 phosphorylation occurred earlier and at lower concentrations of the compound. AG879 also inhibited NGF-induced PLC-gamma 1 phosphorylation, phosphatidylinositol-3 (PI3) kinase activation, the association of the tyrosine-phosphorylated proteins pp100 and pp110 with the p85 subunit of PI-3 kinase, mitogen activated protein and raf-1 kinases, and c-fos induction. In addition, AG879 inhibited NGF-induced neurite outgrowth in PC12 cells. These data indicate that tyrosine kinase activity of the pp140c-trk NGF receptor is essential for the cellular actions of this growth factor.

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Publishing Authors By Initials

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The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemistry

VOLUME: 32

Page Numbers: 4650-8

Journal Abbreviation: Biochemistry

ISSN: 0006-2960

DAY: 4

MONTH: May

YEAR: 1993

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Information

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LANGUAGE: eng

NlmUniqueID: 370623

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Keywords Mesh Terms:

KEYWORDS: Tyrphostins

MESH TERMS: metabolism

Chemical & Substance for Abstract: The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Information

Substance Name: Type C Phospholipases

Registry Number: EC 3.1.4.-

Grant and Affiliation Information for The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor.

AFFILIATION: Department of Physiology, University of Michigan School of Medicine, Ann Arbor 48109.

Country: UNITED STATES

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MEDLINETA: Biochemistry

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