The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Research Abstract Details 

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The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Abstract Text:

Ana Luiza Maia, Dupuis,Alisa Manning,Chunyu Liu,James B Meigs,L Adrienne Cupples,P Reed Larsen,Caroline S Fox,

BACKGROUND: Type 2 deiodinase plays a critical role in thyroid hormone homeostasis. A single nucleotide polymorphism in DIO2 gene (A/G) in humans has been associated with a approximately 20% lower glucose disposal rate and greater insulin resistance in type 2 diabetes (DM2) patients. OBJECTIVE: This study was designed to test whether homozygosity for the DIO2 A/G polymorphism would be associated with risk of DM2 or elevated levels of diabetes intermediate traits. DESIGN AND SETTING: Community-based, longitudinal study. Participants were withdrawn from a subset of unrelated individuals from the Offspring Cohort of the Framingham Heart Study who had DNA collected between 1995 and 1998. METHODS: DNA samples from 1633 participants (mean age, 62 years) underwent genotyping of the DIO2 A/G polymorphism. Incident DM2 and diabetes-related traits (fasting plasma glucose, mean fasting plasma glucose, 2-hour glucose, hemoglobin A(1c), fasting insulin, insulin resistance) were measured. RESULTS: The minor allele (G) frequency was 0.37. Using multivariable regression for intermediate traits and Cox proportional hazards regression for DM2, p values were calculated for two models: Model 1: age, age-squared, sex, and smoking; Model 2: Model 1 + body mass index. There were no significant associations (all p > 0.20) for any trait examined. For DM2 risk, the hazard ratios associated with A/G or G/G relative to the A/A genotype were 1.0 (95% confidence interval [CI] 0.7-1.3) and 1.2 (95% CI 0.7-1.9), respectively. CONCLUSIONS: Our results indicate that in this community-based sample, there is no association of the DIO2 A/G polymorphism with diabetes intermediate trait levels or DM2 risk.

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Publishing Authors By Initials

AL Maia,J Dupuis,A Manning,C Liu,JB Meigs,LA Cupples,PR Larsen,CS Fox,

For similar investigative techniques: genetic techniques: sequence analysis: sequence analysis, dna research abstracts see: investigative techniques: genetic techniques: sequence analysis: sequence analysis, dna research

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The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Thyroid : official journal of the American Thyroid

VOLUME: 17

Page Numbers: 199-202

Journal Abbreviation: Thyroid

ISSN: 1050-7256

DAY: 3

MONTH: Mar

YEAR: 2007

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9104317

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Keywords Mesh Terms:

KEYWORDS: Sequence Analysis, DNA

MESH TERMS: genetics

Chemical & Substance for Abstract: The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Information

Substance Name: Iodide Peroxidase

Registry Number: EC 1.11.1.8

Grant and Affiliation Information for The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.

AFFILIATION: Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. almaia@ufrgs.br

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HC-25195

ACRONYM: HC

MEDLINETA: Thyroid

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