The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Research Abstract Details 

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The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Abstract Text:

S J Tang,P A Hoodless,Z Lu,M L Breitman,R R McInnes,J L Wrana,M Buchwald,

TGFbeta-related factors are critical regulators of vertebrate mesoderm development. However, the signalling cascades required for their function during this developmental process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in P19 cells, and this response is mediated by BMP type I receptors and Smad1. These results suggest that Tlx-2 is a downstream target gene for BMP signalling in the primitive streak where BMP-4 and other TGFbeta-related factors are expressed. Furthermore, disruption of Tlx-2 function leads to early embryonic lethality. Similar to BMP4 and ALK3 mutants, the mutant embryos display severe defects in primitive streak and mesoderm formation. These experiments thus define a BMP/Tlx-2 signalling pathway that is required during early mammalian gastrulation.

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Publishing Authors By Initials

SJ Tang,PA Hoodless,Z Lu,ML Breitman,RR McInnes,JL Wrana,M Buchwald,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 125

Page Numbers: 1877-87

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 19

MONTH: May

YEAR: 1998

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: genetics

Chemical & Substance for Abstract: The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.

AFFILIATION: Department of Genetics, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.

Country: ENGLAND

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MEDLINETA: Development

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