The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts.

The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Research Abstract Details 

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The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Abstract Text:

Hongying Yang,Vered Anzenberg,Kathryn D Held,

Although bystander effects have been shown for some high-LET radiations, few studies have been done on bystander effects induced by heavy-ion radiation. In this study, using a Transwell insert co-culture system, we have demonstrated that irradiation with 1 GeV/nucleon iron ions can induce medium-mediated bystander effects in normal AG01522 human fibroblasts. When irradiated and unirradiated bystander cells were combined in shared medium immediately after irradiation, a two- to threefold increase in the percentage of bystander cells with gamma-H2AX foci occurred as early as 1 h after irradiation and lasted at least 24 h. There was a twofold increase in the formation of micronuclei in bystander cells when they were co-cultured with irradiated cells immediately or 1 or 3 h after irradiation, but there was no bystander effect when the cells were co-cultured 6 h or later after irradiation. In addition, bystander micronucleus formation was observed even when the bystander cells were co-cultured with irradiated cells for only 1 h. This indicates that the crucial signaling to bystander cells from irradiated cells occurs shortly after irradiation. Moreover, both gamma-H2AX focus formation and micronucleus formation in bystander cells were inhibited by the ROS scavengers SOD or catalase or the NO scavenger PTIO. This suggests that ROS and NO play important roles in the initiation of bystander effects. The results with iron ions were similar to those with X rays, suggesting that the bystander responses in this system are independent of LET.

The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Publishing Authors By Initials

H Yang,V Anzenberg,KD Held,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Radiation research

VOLUME: 168

Page Numbers: 292-8

Journal Abbreviation: Radiat. Res.

ISSN: 0033-7587

DAY: 3

MONTH: Sep

YEAR: 2007

The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401245

The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: radiation effects

Chemical & Substance for Abstract: The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Information

Substance Name: Iron Isotopes

Registry Number: 0

Grant and Affiliation Information for The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts.

AFFILIATION: Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. hyang5@partners.org

Country: United States

AGENCY: United States NCI

GRANT: T32 CA009078

ACRONYM: CA

MEDLINETA: Radiat Res

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