The Tim-3 ligand galectin-9 negatively regulates CD8(+) alloreactive T cell and prolongs survival of skin graft.

The Tim-3 ligand galectin-9 negatively regulates CD8(+) alloreactive T cell and prolongs survival of skin graft. Research Abstract Details 

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The Tim-3 ligand galectin-9 negatively regulates CD8(+) alloreactive T cell and prolongs survival of skin graft. Abstract Text:

Feng Wang,Wentao He,Hongmin Zhou,Jin Yuan,Ke Wu,Lijun Xu,Zhonghua Klaus Chen,Feng Wang,Wentao He,Hongmin Zhou,Jin Yuan,Ke Wu,Lijun Xu,Zhonghua Klaus Chen,

CD8(+) alloreactive T cells are the key mediators of accelerated rejection. Vigorous CD8(+) alloreactive T cells responses against alloantigens, which is the main effector mechanism in acute allograft rejection, has been well described. But the molecular mechanisms to dampen activated CD8(+) T cells are largely unknown. On the other hand, Tim-3 is a molecule expressed on terminally differentiated CD4(+) Th1 cells. Engaging Tim-3 with its ligand galectin-9 causes an inhibitory signal, resulting in apoptosis of Th1 cells and negatively regulates Th1 type immunity. However, the question whether CD8(+) T cells express surface molecular Tim-3 has not been fully elucidated. In this study, we have investigated which CD8(+) subset express molecular Tim-3 by flow cytometric assay. In addition, cytotoxic assay was applied to analyze whether CD8(+) alloreactive T cells were sensitive to galectin-9 induced apoptosis. Here, our results demonstrated that Tim-3 was expressed on activated CD8(+) alloreactive T cells (CD8(+)CD44(high)CD62L(low)), but not expressed on naïve CD8(+) T cells. Furthermore, alloreactive CD8(+) cytotoxic T cells were sensitive to galectin-9 induced apoptosis both in vitro and vivo, resulting in attenuation of CD8(+) alloreactive T cells mediated cytotoxicity and prolonged survival of skin graft.

The Tim-3 ligand galectin-9 negatively regulates CD8(+) alloreactive T cell and prolongs survival of skin graft. Publishing Authors By Initials

F Wang,W He,H Zhou,J Yuan,K Wu,L Xu,ZK Chen,F Wang,W He,H Zhou,J Yuan,K Wu,L Xu,ZK Chen,

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The Tim-3 ligand galectin-9 negatively regulates CD8(+) alloreactive T cell and prolongs survival of skin graft. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cellular immunology

VOLUME: 250

Page Numbers: 68-74

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ISSN: 1090-2163

DAY: 18

MONTH: 03

YEAR: 2008

The Tim-3 ligand galectin-9 negatively regulates CD8(+) alloreactive T cell and prolongs survival of skin graft. Information

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LANGUAGE: eng

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Country: United States

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MEDLINETA: Cell Immunol

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