The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders.

The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. Research Abstract Details 

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The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. Abstract Text:

E Koutsilieri,A Rethwilm,C Scheller,E Koutsilieri,A Rethwilm,C Scheller,

RNA interference using small inhibitory RNA (siRNA) has become a powerful tool to downregulate mRNA levels by cellular nucleases that become activated when a sequence homology between the siRNA and a respective mRNA molecule is detected. Therefore siRNA can be used to silence genes involved in the pathogenesis of various diseases associated with a known genetic background. As for many neurodegenerative disorders a causative therapy is unavailable, siRNA holds a promising option for the development of novel therapeutic strategies. Here we discuss different siRNA target strategies aiming for an allele-specific degradation of disease-inducing mRNA and we review the literature in the field of siRNA and its application in animal models of neurodegenerative diseases, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and spinocerebellar ataxia (SCA1).

The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. Publishing Authors By Initials

E Koutsilieri,A Rethwilm,C Scheller,E Koutsilieri,A Rethwilm,C Scheller,

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The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neural transmission. Supplementum

VOLUME:

Page Numbers: 43-9

Journal Abbreviation: J. Neural Transm. Suppl.

ISSN: 0303-6995

DAY: 6

MONTH: 11

YEAR: 2007

The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. Information

Number of References: 44

LANGUAGE: eng

NlmUniqueID: 425126

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AFFILIATION: Institute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

Country: Austria

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MEDLINETA: J Neural Transm Suppl

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