The tetraspan protein EMP2 regulates expression of caveolin-1.

The tetraspan protein EMP2 regulates expression of caveolin-1. Research Abstract Details 

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The tetraspan protein EMP2 regulates expression of caveolin-1. Abstract Text:

Ashley Forbes,Madhuri Wadehra,Sergei Mareninov,Shawn Morales,Kaori Shimazaki,Lynn K Gordon,Jonathan Braun,

Caveolin-1 is the primary component of caveolae and functions in a variety of intracellular activities, including membrane trafficking and signal transduction. EMP2 (epithelial membrane protein 2) is a tetraspan protein recently identified as a novel regulator of caveolin-1 expression. In this study, we analyzed the mechanism of EMP2-mediated caveolin-1 regulation. In NIH 3T3 cells and in the human retinal pigment epithelium cell line (ARPE-19), EMP2 regulates caveolin-1 transcription and more substantially its protein levels. EMP2-mediated down-regulation of caveolin-1 does not affect caveolin-1 translational efficiency, phosphorylation, or proteasome-mediated degradation. Analysis of caveolin-1 protein half-life indicates the EMP2-mediated loss of caveolin-1 occurs rapidly. Protease inhibition and laser confocal microscopy associates this fate with specific intracellular compartmentalization, including early lysosomal delivery. These findings elucidate a new mechanism of caveolin-1 regulation and define an additional role for EMP2 as a key regulator of cell membrane composition.

The tetraspan protein EMP2 regulates expression of caveolin-1. Publishing Authors By Initials

A Forbes,M Wadehra,S Mareninov,S Morales,K Shimazaki,LK Gordon,J Braun,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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The tetraspan protein EMP2 regulates expression of caveolin-1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 26542-51

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 3

MONTH: 07

YEAR: 2007

The tetraspan protein EMP2 regulates expression of caveolin-1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

The tetraspan protein EMP2 regulates expression of caveolin-1. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: The tetraspan protein EMP2 regulates expression of caveolin-1. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for The tetraspan protein EMP2 regulates expression of caveolin-1.

AFFILIATION: Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD48540

ACRONYM: HD

MEDLINETA: J Biol Chem

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