The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis.

The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Research Abstract Details 

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The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Abstract Text:

Everton F Silva,Marco A Medeiros,Alan J A McBride,Jim Matsunaga,Gabriela S Esteves, Ramos,Cleiton S Santos, Croda,Akira Homma,Odir A Dellagostin,David A Haake,Mitermayer G Reis,Albert I Ko,Everton F Silva,Marco A Medeiros,Alan J A McBride,Jim Matsunaga,Gabriela S Esteves, Ramos,Cleiton S Santos, Croda,Akira Homma,Odir A Dellagostin,David A Haake,Mitermayer G Reis,Albert I Ko,

Subunit vaccines are a potential intervention strategy against leptospirosis, which is a major public health problem in developing countries and a veterinary disease in livestock and companion animals worldwide. Leptospiral immunoglobulin-like (Lig) proteins are a family of surface-exposed determinants that have Ig-like repeat domains found in virulence factors such as intimin and invasin. We expressed fragments of the repeat domain regions of LigA and LigB from Leptospira interrogans serovar Copenhageni. Immunization of Golden Syrian hamsters with Lig fragments in Freund's adjuvant induced robust antibody responses against recombinant protein and native protein, as detected by ELISA and immunoblot, respectively. A single fragment, LigANI, which corresponds to the six carboxy-terminal Ig-like repeat domains of the LigA molecule, conferred immunoprotection against mortality (67-100%, P<0.05) in hamsters which received a lethal inoculum of L. interrogans serovar Copenhageni. However, immunization with this fragment did not confer sterilizing immunity. These findings indicate that the carboxy-terminal portion of LigA is an immunoprotective domain and may serve as a vaccine candidate for human and veterinary leptospirosis.

The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Publishing Authors By Initials

EF Silva,MA Medeiros,AJ McBride,J Matsunaga,GS Esteves,JG Ramos,CS Santos,J Croda,A Homma,OA Dellagostin,DA Haake,MG Reis,AI Ko,EF Silva,MA Medeiros,AJ McBride,J Matsunaga,GS Esteves,JG Ramos,CS Santos,J Croda,A Homma,OA Dellagostin,DA Haake,MG Reis,AI Ko,

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The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Vaccine

VOLUME: 25

Page Numbers: 6277-86

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 14

MONTH: 06

YEAR: 2007

The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis.

AFFILIATION: Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Brazil.

Country: Netherlands

AGENCY: United States FIC

GRANT: TW00919

ACRONYM: TW

MEDLINETA: Vaccine

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