The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase.

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Abstract Text:

Svetlana Makovets,Tanya L Williams,Elizabeth H Blackburn,Svetlana Makovets,Tanya L Williams,Elizabeth H Blackburn,Svetlana Makovets,Tanya L Williams,Elizabeth H Blackburn,

Telomeres are an unusual component of the genome because they do not encode genes, but their structure and cellular maintenance machinery (which we define as "telotype") are essential for chromosome stability. Cells can switch between different phenotypic states. One such example is when they switch from maintenance mediated by telomerase (TERT telotype) to one of the two alternative mechanisms of telomere preservation (ALT I and ALT II telotype). The nature of this switch is largely unknown. Reintroduction of telomerase into ALT II, but not ALT I, yeast led to the loss of their ability to survive a second round of telomerase withdrawal. Mating-based genetic analysis of ALT I and II revealed that both types of telomerase-independent telomere maintenance are inherited as a non-Mendelian trait dominant over senescence (SEN telotype). Additionally, inheritance of ALT I and ALT II did not depend on either the mitochondrial genome or a prion-based mechanism. Type I, but not type II, survivor cells exhibited impaired gene silencing, potentially connecting the switch to the ALT telotype epigenetic changes. These data provide evidence that nonprion epigenetic-like mechanisms confer flexibility on cells as a population to adjust to the life-threatening situation of telomerase loss, allowing cells to switch from TERT to ALT telotypes that can sustain viable populations.

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Publishing Authors By Initials

S Makovets,TL Williams,EH Blackburn,S Makovets,TL Williams,EH Blackburn,S Makovets,TL Williams,EH Blackburn,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genetics

VOLUME: 178

Page Numbers: 245-57

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 18

MONTH: Jan

YEAR: 2008

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase.

AFFILIATION: Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Genetics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase Related Publications

• A multinuclear copper(I) cluster forms the dimerization interface in copper-loaded human copper chaperone for superoxide dismutase.
• A newly recognised strain of Staphylococcus aureus associated with epidemics in six hospitals.
• A preschool program at East York Health Unit.
• A short history of dentistry in ancient times.
• A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge.
• Breast-feeding Internet Resources.
• Cardiovascular survey methods.
• Coarctation of the aorta in a man, aged 63 years.
• Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women.
• Diet and breast cancer recurrence.
• Disequilibrium due to a vitamin B6 megadose supplement.
• Expression and suppression of human telomerase RNA.
• FLUOROMETHOLONE (NSC-33001) AS A PALLIATIVE IN ADVANCED GASTROINTESTINAL CARCINOMA.
• Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice.
• Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres.
• Insidious onset neck pain - a symptom not to be dismissed.
• Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor.
• Ligand dependent release of activated neutrophil collagenase--a role for surface bound IgG in the degradation of articular collagens.
• MONOSEMICARBAZONE OF ADRENOCHROME (ADRENOXYL) AND CATARACT SURGERY EFFECT ON CAPILLARY RESISTANCE AND INCIDENCE OF HYPHAEMA.
• One-solvent polymorph screen of carbamazepine.
• Proteins synthesized in medial hypothalamus and transported to midbrain in estrogen-treated female rats.
• Selected internet resources relating to trauma and violence in women and infants.
• Spatial turnover in the global avifauna.
• The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase.
• The low-fat imperative.
• The role of lead in the reduction of the erythrocyte sedimentation rate by hyaluronidase.
• Thymus organogenesis and development of the thymic stroma.
• Use of 2alpha-methyldihydrotestosterone propionate in treatment of advanced cancer of the breast: a group report.
• Using aliens to explore how our planet works.
• VINCRISTINE (NSC-67574) THERAPY OF ADULT PATIENTS WITH SOLID TUMORS.