The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells.

The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells. Research Abstract Details 

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The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells. Abstract Text:

Elimelda Moige Ongeri,Michael F Verderame,James M Hammond,Elimelda Moige Ongeri,Michael F Verderame,James M Hammond,Elimelda Moige Ongeri,Michael F Verderame,James M Hammond,Elimelda Moige Ongeri,Michael F Verderame,James M Hammond,

We have established the gene for IGF binding protein-3 (IGFBP-3) as a target for FSH action. FSH effects on this gene require the PKA pathway as well as the PI-3 kinase and MAPK pathways. At the IGFBP-3 promoter, FSH effects depend on a site for TATA box binding protein (TBP) and formation of a high molecular weight transcription complex. To further elucidate FSH effects on the downstream events involving the TBP site, we cloned a pig TAF4b cDNA into a P-Flag expression vector. By co-transfecting granulosa cells with the IGFBP-3 promoter, we found that TAF4b mimics and enhances FSH induction of IGFBP-3 reporter activity. Using RT-PCR we showed that FSH stimulates expression of TAF4b. This would suggest that the role of TAF4b in follicular development is regulated by FSH. TAF4b may thus be the TFIID component that binds to the TBP site on the IGFBP-3 promoter and is essential for FSH induction of IGFBP-3.

The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells. Publishing Authors By Initials

EM Ongeri,MF Verderame,JM Hammond,EM Ongeri,MF Verderame,JM Hammond,EM Ongeri,MF Verderame,JM Hammond,EM Ongeri,MF Verderame,JM Hammond,

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The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular and cellular endocrinology

VOLUME: 278

Page Numbers: 29-35

Journal Abbreviation: Mol. Cell. Endocrinol.

ISSN: 0303-7207

DAY: 19

MONTH: 08

YEAR: 2007

The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells. Information

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LANGUAGE: eng

NlmUniqueID: 7500844

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Grant and Affiliation Information for The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells.

AFFILIATION: Pennsylvania State University, College of Medicine, Hershey Medical Center, Hershey, PA 17033, United States.

Country: Ireland

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MEDLINETA: Mol Cell Endocrinol

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