The structure and function of Francisella lipopolysaccharide.

The structure and function of Francisella lipopolysaccharide. Research Abstract Details 

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The structure and function of Francisella lipopolysaccharide. Abstract Text:

John S Gunn,Robert K Ernst,

A key factor in the biology of Francisella spp. is lipopolysaccharide (LPS). Francisella LPS has many unique structural properties and poorly activates proinflammatory responses due to its lack of interaction with toll-like receptor 4 (TLR4). The LPS of this organism can be modified by various carbohydrates including glucose, mannose and galactosamine, which affect various aspects of virulence. Spontaneously occurring colony variants of F. tularensis have altered LPS. This altered LPS may account for the novel phenotypes of these variants that include effects on susceptibility to killing by normal human serum, intracellular survival and animal virulence. Mutants devoid of O-antigen (directed mutants in O-antigen biosynthetic genes) show reduced intracellular survival and mouse virulence. Thus, this surface component is important in F. tularensis pathogenesis, and the inability of the LPS to alarm the immune system coupled with its frequent modification/alteration likely aid the success of this pathogen during human infection.

The structure and function of Francisella lipopolysaccharide. Publishing Authors By Initials

JS Gunn,RK Ernst,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

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The structure and function of Francisella lipopolysaccharide. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1105

Page Numbers: 202-18

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 29

MONTH: 03

YEAR: 2007

The structure and function of Francisella lipopolysaccharide. Information

Number of References: 52

LANGUAGE: eng

NlmUniqueID: 7506858

The structure and function of Francisella lipopolysaccharide. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: immunology

Chemical & Substance for Abstract: The structure and function of Francisella lipopolysaccharide. Information

Substance Name: Lipopolysaccharides

Registry Number: 0

Grant and Affiliation Information for The structure and function of Francisella lipopolysaccharide.

AFFILIATION: The Center for Microbial Interface Biology, The Ohio State University, Biomedical Research Tower, Rm. 1006, 460 W. 12th Ave., Columbus, OH 43210-1214, USA. gunn.43@osu.edu

Country: United States

AGENCY: United States NIAID

GRANT: 1-U54-AI-57141

ACRONYM: AI

MEDLINETA: Ann N Y Acad Sci

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