The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding.

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Research Abstract Details 

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The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Abstract Text:

S Jack Lin,Thomas F Lerch,Robert W Cook,Theodore S Jardetzky,Teresa K Woodruff,

The transforming growth factor-beta (TGF-beta) superfamily is a large group of structurally related growth factors that play prominent roles in a variety of cellular processes. The importance and prevalence of TGF-beta signaling are also reflected by the complex network of check points that exist along the signaling pathway, including a number of extracellular antagonists and membrane-level signaling modulators. Recently, a number of important TGF-beta crystal structures have emerged and given us an unprecedented clarity on several aspects of the signal transduction process. This review will highlight these latest advances and present our current understanding on the mechanisms of specificity and regulation on TGF-beta signaling outside the cell.

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Publishing Authors By Initials

SJ Lin,TF Lerch,RW Cook,TS Jardetzky,TK Woodruff,

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The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Journal Published:

PUBLICATION TYPE: Review

Journal: Reproduction (Cambridge, England)

VOLUME: 132

Page Numbers: 179-90

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ISSN: 1470-1626

DAY: 3

MONTH: Aug

YEAR: 2006

The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding.

AFFILIATION: Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.

Country: England

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