The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component.

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Abstract Text:

C J Reissig,J R Eckler,R A Rabin,K C Rice,J C Winter,

A previous investigation in our laboratory found that the stimulus effects of the 5-HT(2A) agonist, LSD, are potentiated by 5-HT(1A) receptor agonists including the prototypic agonist, 8-OH-DPAT. Also suggestive of behaviorally relevant interactions between 5-HT(1A) and 5-HT(2A) receptors are behavioral analyses of locomotor activity, head-twitch response, forepaw treading and production of the serotonin syndrome; in some instances effects are augmented, in other, diminished. These observations led us in the present investigation to test the hypothesis that stimulus control by 8-OH-DPAT [0.2 mg/kg; 15 min pretreatment time] is modulated by 5-HT(2A) ligands. Stimulus control was established with 8-OH-DPAT in a group of 10 rats. A two-lever, fixed ratio 10, positively reinforced task with saline controls was employed. As shown previously, stimulus control by 8-OH-DPAT and the generalization of 8-OH-DPAT to the 5-HT(1A) partial agonist, buspirone, was completely blocked by the selective 5-HT(1A) antagonist, WAY-100635. In contrast, antagonism by the selective 5-HT(2A) antagonist, M100907 [0.1 mg/kg; 30 min pretreatment time], of 8-OH-DPAT and of the generalization of 8-OH-DPAT to buspirone was statistically significant but less than complete. In light of our previous conclusions regarding the interactions of 5-HT(1A) agonists with LSD-induced stimulus control, the present data suggest that the interaction between 5-HT(1A) and 5-HT(2A) receptors is bidirectional in drug discrimination studies.

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Publishing Authors By Initials

CJ Reissig,JR Eckler,RA Rabin,KC Rice,JC Winter,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 88

Page Numbers: 312-7

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 19

MONTH: 09

YEAR: 2007

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 367050

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component.

AFFILIATION: Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pharmacol Biochem Behav

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT2A receptor-mediated component Related Publications

• A piece of my mind. Perceptions.
• A pyrazolate-based metalorganic tantalum precursor that exhibits high thermal stability and its use in the atomic layer deposition of ta(2)o(5).
• Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs.
• Arg-Pro-X-Ser/Thr is a consensus phosphoacceptor sequence for the meiosis-specific Ime2 protein kinase in Saccharomyces cerevisiae.
• Candida (Monilia) infections in children.
• Capturing the interaction potential of amyloidogenic proteins.
• Diarrhoea, ascites and eosinophilia: An unusual triad.
• Editorial: networking clinical research.
• Effects of periparturient systemic treatment with penethamate hydriodide on udder health and milk yield of dairy heifers.
• Elegance, silence and nonsense in the mutations literature for solid tumors.
• Ex-Vivo Expansion of CFU-GM and BFU-E in Unselected PBMC Cultures with Flt3L is Enhanced by Autologous Plasma.
• Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT(1A) and 5-HT(2A) receptors in rodents.
• Home stroke rehabilitation for the upper limbs.
• Improving the accuracy of feature extraction for flexible endoscope calibration by spatial super resolution.
• Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice.
• Mechanism of islet amyloid polypeptide fibrillation at lipid interfaces studied by infrared reflection absorption spectroscopy.
• Photoprotection, photosynthesis and growth of tropical tree seedlings under near-ambient and strongly reduced solar ultraviolet-B radiation.
• Pressure tuning of the morphology of heterogeneous lipid vesicles: a two-photon-excitation fluorescence microscopy study.
• Propionic acid accumulation and degradation during restart of a full-scale anaerobic biowaste digester.
• Quantum nonlocality and beyond: limits from nonlocal computation.
• Reflections on the knowledge base for obstetric fistula.
• Repertoires of aggregation-resistant human antibody domains.
• Stability of spikes in the shadow Gierer-Meinhardt system with Robin boundary conditions.
• The role of thrombomodulin in malignancy.
• The stimulus effects of 8-OH-DPAT: Evidence for a 5-HT(2A) receptor-mediated component.
• The temporal representation of the delay of dynamic iterated rippled noise with positive and negative gain by single units in the ventral cochlear nucleus.
• XXYY syndrome with schizophrenia: implications for genetic research in psychotic spectrum disorders.
• [In Process Citation]
• [In Process Citation]
• pH-induced protonation of lysine in aqueous solution causes chemical shifts in X-ray photoelectron spectroscopy.