The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Abstract Text:

Saso Cemerski,Jayajit Das,Jason Locasale,Phoebe Arnold,Emanuele Giurisato,Mary A Markiewicz,Daved Fremont,Paul M Allen,Arup K Chakraborty,Andrey S Shaw,

T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclear. We describe results showing that a peptide exhibiting many hallmarks of a weak agonist stimulates T cells to proliferate more than the wild-type agonist ligand. An in silico approach suggested that the inability to form the central supramolecular activation cluster (cSMAC) could underlie the increased proliferation. This conclusion was supported by experiments that showed that enhancing cSMAC formation reduced stimulatory capacity of the weak peptide. Our studies highlight the fact that a complex interplay of factors determines the quality of a T cell antigen.

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Publishing Authors By Initials

S Cemerski,J Das,J Locasale,P Arnold,E Giurisato,MA Markiewicz,D Fremont,PM Allen,AK Chakraborty,AS Shaw,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

PUBMED ID PMID:

MEDLINE DATE:

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Immunity

VOLUME: 26

Page Numbers: 345-55

Journal Abbreviation: Immunity

ISSN: 1074-7613

DAY: 8

MONTH: 03

YEAR: 2007

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432918

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Information

Substance Name: natural killer cell activating receptors

Registry Number: 0

Grant and Affiliation Information for The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.

AFFILIATION: Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI071195-01

ACRONYM: AI

MEDLINETA: Immunity

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse Related Publications

• A cricket Gene Index: a genomic resource for studying neurobiology, speciation, and molecular evolution.
• Age-associated defect in human TLR-1/2 function.
• Aluminum adjuvant linked to gulf war illness induces motor neuron death in mice.
• Biotransformation of maximakinin, a bradykinin-related nonadecapeptide from toad venom, by mammalian kallikrein and salivary proteases.
• Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources.
• Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.
• Ct05 mechanical valve or tissue valve: do patients regret their decision?
• Ct23 what's new in ICU.
• Ct25 cpap: an overview and current applications.
• Ct27 a history of errors and the christchurch solution.
• Ct32 when to call the surgeon.
• Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice.
• Do the predictors of child conduct problems vary by high- and low-levels of socioeconomic and neighborhood risk?
• Ending the splits.
• Essentials of sleep recordings in Drosophila: moving beyond sleep time.
• From Sydney to Athens: preparing for the Olympic and Paralympic Games.
• Identification of a biomarker for sleep drive in flies and humans.
• Impact of neighborhood disadvantage on overt behavior problems during early childhood.
• Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study.
• Mitochondrial DNA haplogroups and amyotrophic lateral sclerosis.
• Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults.
• Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study.
• Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
• Synthesis and stereochemical assignment of brasilibactin A.
• Synthesis of kaempferitrin.
• Testing mediators of intervention effects in randomized controlled trials: An evaluation of two eating disorder prevention programs.
• The African orphan crisis and international adoption.
• The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.
• Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.
• [The self-training of a therapist : a demystification process.]