The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease.

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Abstract Text:

K J Murphy,

PURPOSE: To define the spectrum of abnormalities in sickle-cell disease, including infarction, atrophy, and hemorrhage, that are identified by brain MR imaging. METHODS: All MR studies included T1, T2, and intermediate pulse sequences. Images were interpreted without knowledge of the clinical history or neurologic examination findings. Brain MR imaging was performed in 312 children with sickle-cell disease. RESULTS: Seventy patients (22%) had infarction/ischemia and/or atrophy, infarction/ischemia was noted in 39 children (13%) who had no history of a stroke (the "silent" group). The prevalence rates for silent lesions were 17% for sickle-cell anemia and 3% for hemoglobin sickle-cell disease. For patients with sickle-cell anemia and a history of cerebrovascular accident, infarction/ischemia lesions typically involved both cortex and deep white matter, while silent lesions usually were confined to deep white matter. Within the age range studied, the prevalence of infarction/ischemia did not increase significantly with age, although older patients with lesions had more lesions than did younger patients with lesions. CONCLUSIONS: Brain MR imaging showed infarction/ischemia in the absence of a recognized cerebrovascular accident in 13% of patients. The prevalence of these lesions did not increase significantly between the ages of 6 and 14 years, suggesting that lesions are present by age 6. However, the increase in the average number of lesions per patient with age may indicate progressive brain injury.

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Publishing Authors By Initials

KJ Murphy,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research

PUBMED ID PMID:

MEDLINE DATE:

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJNR. American journal of neuroradiology

VOLUME: 17

Page Numbers: 965-72

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: May

YEAR: 1996

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Keywords Mesh Terms:

KEYWORDS: Prevalence

MESH TERMS: pathology

Chemical & Substance for Abstract: The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease.

AFFILIATION: Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, Calif 90048, USA.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: AJNR Am J Neuroradiol

REFSOURCE: AJNR Am J Neuroradiol. 1997 Mar;18(3):59

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease Related Publications

• A comparison of perforated cellophane and plasma clot slide technics for culturing human tumors.
• Abdominal pregnancy.
• Antimalarial psychosis revisited.
• Application of immunohistochemistry in the diagnosis of non-hodgkin and hodgkin lymphoma.
• Application of ultrasonic assisted extraction of chemically diverse organic compounds from soils and sediments.
• Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children.
• Energy flow - a vital theme in injury and infection.
• Engineering oilseeds to produce nutritional fatty acids.
• Expert judgment assessment of the mortality impact of changes in ambient fine particulate matter in the U.S.
• Glycerol turnover and kinetics of exogenous fat in surgical patients.
• Homologous serum jaundice; a case report.
• Introduction.
• Is the late preterm infant more vulnerable to gray matter injury than the term infant?
• Medicare payment to hospitals for a return on capital: the influence of federal budget policy on judicial decision-making.
• Muscle and plasma amino acids after Neopham therapy in adult surgical patients.
• Myelin Abnormalities without Oligodendrocyte Loss in Periventricular Leukomalacia.
• National scientific facilities and their science impact on nonbiomedical research.
• Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort.
• Resting energy expenditure in injured, septic, and malnourished adult patients on intravenous diets.
• Sir David Cuthbertson and Arvid Wretlind-Pillars of ESPEN.
• Specificity and sensitivity of dynamic posturography. A retrospective analysis.
• Studies in display symbol legibility. 8. Legibility of common five-letter words. ESD-TR-65-385. TM-4239.
• Sudden death in toddlers with viral meningitis, massive cerebral edema, and neurogenic pulmonary edema and hemorrhage: report of two cases.
• Tech tip: the use of EDTA when whole blood samples fail to clot quickly.
• The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population.
• The influence of diet on iron absorption; the interrelation of iron and phosphorus.
• The role of the non-governmental agency in disaster aid.
• The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease.
• Tonsillectomy and poliomyelitis in Cuyahoga County, Ohio.
• Uncertainty in BRCA1 cancer susceptibility testing.