The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Research Abstract Details 

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The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Abstract Text:

Alison E Meyer,Nai-Jung Hung,Peizhen Yang,Arlen W Johnson,Elizabeth A Craig,

J-proteins and Hsp70 chaperones function together in diverse cellular processes. We identified a cytosolic J-protein, Jjj1, of Saccharomyces cerevisiae that is associated with 60S ribosomal particles. Unlike Zuo1, a 60S subunit-associated J-protein that is a component of the chaperone machinery that binds nascent polypeptide chains upon their exit from the ribosome, Jjj1 plays a role in ribosome biogenesis. Cells lacking Jjj1 have phenotypes very similar to those lacking Rei1, a ribosome biogenesis factor associated with pre-60S ribosomal particles in the cytosol. Jjj1 stimulated the ATPase activity of the general cytosolic Hsp70 Ssa, but not Ssb, Zuo1's ribosome-associated Hsp70 partner. Overexpression of Jjj1, which is normally approximately 40-fold less abundant than Zuo1, can partially rescue the phenotypes of cells lacking Zuo1 as well as cells lacking Ssb. Together, these results are consistent with the idea that Jjj1 normally functions with Ssa in a late, cytosolic step of the biogenesis of 60S ribosomal subunits. In addition, because of its ability to bind 60S subunits, we hypothesize that Jjj1, when overexpressed, is able to partially substitute for the Zuo1:Ssb chaperone machinery by recruiting Ssa to the ribosome, facilitating its interaction with nascent polypeptide chains.

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Publishing Authors By Initials

AE Meyer,NJ Hung,P Yang,AW Johnson,EA Craig,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 1558-63

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 22

MONTH: 01

YEAR: 2007

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: physiology

Chemical & Substance for Abstract: The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis. Information

Substance Name: SSA1 protein, S cerevisiae

Registry Number: EC 3.6.1.3

Grant and Affiliation Information for The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.

AFFILIATION: Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, WI 53706, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM53655

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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