The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases.

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Abstract Text:

L A Turnberg,

In many diarrhoeal diseases the intestinal mucosa is stimulated to secrete salt and water. This occurs in diarrhoea as a result of several bacterial toxins, is associated with inflammation and release of inflammatory mediators, and, in many instances, occurs when a neural element is evident. An understanding of the basic underlying mechanisms of secretion could lead to improvements in therapy. Development of vaccines against cholera is showing promise, and a knowledge of the complex field of inflammatory mediators, many of which provoke secretion, provides a foundation for development of more specific and selective anti-inflammatory agents. A detailed understanding of the complicated intracellular second-messenger systems, which are switched on by externally perceived signals, and of the ion transport responses, which are responsible for secretion, may lead to the development of specific anti-diarrhoeal drugs. Meanwhile, the message that oral rehydration therapy for severe diarrhoea, including cholera, is successful, should continue to be widely promulgated and taken up.

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Publishing Authors By Initials

LA Turnberg,

For similar second messenger systems research abstracts see: second messenger systems research

PUBMED ID PMID:

MEDLINE DATE:

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 175

Page Numbers: 85-92

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1990

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Information

Number of References: 31

LANGUAGE: eng

NlmUniqueID: 437034

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Keywords Mesh Terms:

KEYWORDS: Second Messenger Systems

MESH TERMS: physiology

Chemical & Substance for Abstract: The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases. Information

Substance Name: Guanylate Cyclase

Registry Number: EC 4.6.1.2

Grant and Affiliation Information for The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases.

AFFILIATION: University Dept. of Medicine, Hope Hospital, Salford, U.K.

Country: NORWAY

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Scand J Gastroenterol Suppl

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases Related Publications

• Abnormalities in intestinal electrolyte transport in congenital chloridorrhoea.
• Alkali secretion by isolated rabbit gastric mucosa: effects of non-steroidal anti-inflammatory drugs and prostaglandins.
• Antisecretory activity of opiates in vitro and in vivo in man.
• Effects of non-steroidal anti-inflammatory drugs and prostaglandins on alkali secretion by rabbit gastric fundus in vitro.
• Gastric mucosal defence mechanisms.
• Liver transplantation in man after an extended period of preservation by a simple technique.
• The influence of secretin on ion transport in the human jejunum.
• The small intestine: prospects for therapeutic approaches in secretory diarrhoeal diseases.