[The sinus node itself also plays a role in heart rate slowing down during postnatal development]

[The sinus node itself also plays a role in heart rate slowing down during postnatal development] Research Abstract Details 

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[The sinus node itself also plays a role in heart rate slowing down during postnatal development] Abstract Text:

Zhi-Fang Yang,Ci-Zhen Li,Qian Li,Xi-Jin Wang,Yuan-Mou Liu,

The slowing down mechanism of heart rate during growth of the body after birth was studied in isolated rabbit heart and sinus node (SN) preparation with Langendorff perfusion method, conventional microelectrode recording and perforated patch for recording pacemaker current I(f). The radioimmunoassay was also used to measure the concentration of cAMP within SN cells. The results indicate that without the influence of nervous and humoral factors, the spontaneous heart rate would also become slower as the rabbit grew older, which is due to the decrease of spontaneous depolarized rate of phase 4 in SN cells. The negative directed shift of the threshold potential of I(f) and the decrease in cAMP concentration within SN cells may be responsible for the phenomenon. The results obtained suggest that besides the nervous and humoral factors which influence the heart rate, the changes in automaticity of SN cell itself may take part in the slowing down process as the body grows up.

[The sinus node itself also plays a role in heart rate slowing down during postnatal development] Publishing Authors By Initials

ZF Yang,CZ Li,Q Li,XJ Wang,YM Liu,

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[The sinus node itself also plays a role in heart rate slowing down during postnatal development] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 54

Page Numbers: 282-6

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ISSN: 0371-0874

DAY: 25

MONTH: Aug

YEAR: 2002

[The sinus node itself also plays a role in heart rate slowing down during postnatal development] Information

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LANGUAGE: chi

NlmUniqueID: 20730130

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AFFILIATION: Department of Physiology, Shanghai Second Medical University, Shanghai 200025. liuyuanm@public6.sta.net.cn

Country: China

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MEDLINETA: Sheng Li Xue Bao

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