The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses.

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Abstract Text:

Meirav Trebicz-Geffen,Zvi Nevo,Zoharia Evron,Natalia Posternak,Tova Glaser,Mati Fridkin,Yehuda Kollander,Dror Robinson,

Hereditary osteochondromas are often caused by mutation in the EXT1 gene. The lesions are typified by formation of a "pseudo" growth plate like lesion growing at 60 degrees to the normal growth direction of the bone. Such lesions can be mimicked surgically by reverting the position--the polarity of the zone of LaCroix. The current study attempts to compare the pathology between EXT1 gene expression in humans and surgically created osteochondroma pathology in a rat model. Tissues of human bunion, human embryonal tissue, and human adult cartilage as well as normal rat epiphyses served as controls. Rats were operated on and a 60 degree span of the ring of LaCroix was inverted as described by Delgado (Delgado, E., Rodriguez, J. I., Serada, A., Tellez, M., and Pariagoa, R.. Clin. Orthop. 201, 251-258 (1985)). The surgically created osteochondromas were assessed by histology, histochemistry, and immunohistochemistry. The findings show that the surgically created lesions contain only a small amount of FGF receptor 3 (FGFR3) expressed on mesenchymal stem cells located in the perichondrium, as compared to the cell population carrying FGFR3 in the contralateral limb. Indian hedgehog and Bcl2 are downregulated, while BMP-2 is overexpressed in the operated limb, compared to the LaCroix ring of the contralaetral limb. The shortage, as well as the disturbed migration routes of the residual mesenchymal stem cells in surgically created osteochondromas leads eventually to resorption of the pathological elements. In search of additional markers characterizing such pathological structures composed of mesenchymal stem cells and cartilaginous and bony cells, EXT1 gene was found to be expressed in the surgically created osteochondromas, like in normal growth plates. Nitric oxide synthase was also expressed like in adult cartilage, though tumor necrosis factor alpha typifying Bunion formation was absent. In summary, surgically created osteochondromas lack the massive and continuous population of mesenchymal stem cells with Bcl2 expression. However, the small residual mesenchymal cell population gives rise to short-lived EXT1-expressing cells that disappear eventually due to spontaneous resorption.

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Publishing Authors By Initials

M Trebicz-Geffen,Z Nevo,Z Evron,N Posternak,T Glaser,M Fridkin,Y Kollander,D Robinson,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental and molecular pathology

VOLUME: 74

Page Numbers: 40-8

Journal Abbreviation: Exp. Mol. Pathol.

ISSN: 0014-4800

DAY: 19

MONTH: Feb

YEAR: 2003

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370711

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses. Information

Substance Name: Receptor, Fibroblast Growth Factor, Type

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses.

AFFILIATION: Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Mol Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses Related Publications

• A basic program to determine outliers in biopharmaceutical analysis using the Nair criterion.
• Asymmetric fraunhofer diffraction from roller-blade slits.
• Co-localization of glycine and gaba immunoreactivity in interneurons in Macaca monkey cerebellar cortex.
• Comparative three-dimensional imaging of living neurons with confocal and atomic force microscopy.
• Detection of problem-drinkers in an emergency department using a breathalyser and questionnaire.
• Effects of intrauterine challenge with Leptospira interrogans serovar hardjo on fertility in cattle.
• Explanation of spin-lattice relaxation rates of spin labels obtained with multifrequency saturation recovery EPR.
• Geographic Information Systems and the Selection of Priority Areas for Control of Tsetse-transmitted Trypanosomiasis in Africa.
• HPLC procedure for the determination of some potential fluphenazine metabolites in urine.
• Identification of enzymatic degradation products of luteinizing hormone releasing hormone (LHRH)/[D-Ala6] LHRH in rabbit mucosal homogenates.
• Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape.
• Modification of the effect of tamoxifen, cis-platin, DTIC, and interferon-alpha 2b on human melanoma cells in culture by a mixture of vitamins.
• Monoamine oxidase inhibitors: a new generation.
• Mortality of intravenous drug users: attenders of the Wellington Drug Clinic, 1972-89.
• Neurochemical and behavioral effects of bupropion and mecamylamine in the presence of nicotine.
• Oral neoplasms of children.
• Pinealectomy does not affect diurnal PER2 expression in the rat limbic forebrain.
• Protein kinase C-dependent remodeling of glutamate transporter function.
• Public and private intervention rates in obstetric practice.
• Pulmonary tuberculosis: the primary lesion; specific vs. nonspecific therapy.
• Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis.
• Spotlight on pioglitazone in type 2 diabetes mellitus.
• Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis.
• Technology can't replace compassion in health care.
• The absence of adaptive changes in tissue activities of glutathione-S-transferase, superoxide dismutase and catalase following selenium and vitamin E supplementation in subjects with low selenium status.
• The determination of nadolol in biological samples using high-performance liquid chromatography.
• The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses.
• The truth about colorectal cancer.
• The use of complementary and alternative therapies in dogs and cats with cancer.
• Vitamin E improves cell-mediated immunity in the burned mouse: a preliminary study.