The sequence of events that underlie quantal transmission at central glutamatergic synapses.

The sequence of events that underlie quantal transmission at central glutamatergic synapses. Research Abstract Details 

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The sequence of events that underlie quantal transmission at central glutamatergic synapses. Abstract Text:

John E Lisman,Sridhar Raghavachari,Richard W Tsien,

The properties of synaptic transmission were first elucidated at the neuromuscular junction. More recent work has examined transmission at synapses within the brain. Here we review the remarkable progress in understanding the biophysical and molecular basis of the sequential steps in this process. These steps include the elevation of Ca2+ in microdomains of the presynaptic terminal, the diffusion of transmitter through the fusion pore into the synaptic cleft and the activation of postsynaptic receptors. The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity.

The sequence of events that underlie quantal transmission at central glutamatergic synapses. Publishing Authors By Initials

JE Lisman,S Raghavachari,RW Tsien,

For similar nervous system: synapses: synaptic vesicles research abstracts see: nervous system: synapses: synaptic vesicles research

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The sequence of events that underlie quantal transmission at central glutamatergic synapses. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature reviews. Neuroscience

VOLUME: 8

Page Numbers: 597-609

Journal Abbreviation: Nat. Rev. Neurosci.

ISSN: 1471-003X

DAY: 3

MONTH: Aug

YEAR: 2007

The sequence of events that underlie quantal transmission at central glutamatergic synapses. Information

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LANGUAGE: eng

NlmUniqueID: 100962781

The sequence of events that underlie quantal transmission at central glutamatergic synapses. Keywords Mesh Terms:

KEYWORDS: Synaptic Vesicles

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: The sequence of events that underlie quantal transmission at central glutamatergic synapses. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for The sequence of events that underlie quantal transmission at central glutamatergic synapses.

AFFILIATION: Brandeis University, Department of Biology, MS 008, 415 South Street, Waltham, Massachusetts 02454-9110, USA. lisman@brandeis.edu

Country: England

AGENCY: United States NINDS

GRANT: R01 NS50944

ACRONYM: NS

MEDLINETA: Nat Rev Neurosci

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