The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Research Abstract Details 

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The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Abstract Text:

Xiao-Rong Peng,Zhengping Jia,Yu Zhang,Jerry Ware,William S Trimble,

Septins are GTPases required for the completion of cytokinesis in a variety of organisms, yet their role in this process is not known. Septins may have additional functions since the mammalian septin CDCrel-1 is predominantly expressed in the nervous system, a largely postmitotic tissue. While relatively little is known about the function of this protein, we have previously shown that it is involved in regulated secretion. In addition, the gene encoding this protein maps to a locus often deleted in velo-cardiofacial and DiGeorge syndromes, and CDCrel-1 has recently been shown to be a direct target of the E3 ubiquitin ligase activity of Parkin, a causative agent in autosomal recessive forms of Parkinson's disease. Here we show that CDCrel-1 expression rises at the time of synaptic maturation and that CDCrel-1 is present in a complex that includes the septins Nedd5 and CDC10. To investigate its function in the nervous system, we generated homozygotic CDCrel-1 null mice and showed that these mice appear normal with respect to synaptic properties and hippocampal neuron growth in vitro. Moreover, we found that while the expression of a number of synaptic proteins is not affected in the CDCrel-1 mutant mice, the expression of other septins is altered. Together, these data suggest that CDCrel-1 is not essential for neuronal development or function, and that changes in expression of other septins may account for its functional redundancy.

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Publishing Authors By Initials

XR Peng,Z Jia,Y Zhang,J Ware,WS Trimble,

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The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 22

Page Numbers: 378-87

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 6

MONTH: Jan

YEAR: 2002

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109087

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Keywords Mesh Terms:

KEYWORDS: Zinc Fingers

MESH TERMS: physiology

Chemical & Substance for Abstract: The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Information

Substance Name: Sept2 protein, mouse

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.

AFFILIATION: Programmes in Cell Biology. Brain and Behavior, Hospital for Sick Children, Toronto, Ontario, Canada.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL069951-01

ACRONYM: HL

MEDLINETA: Mol Cell Biol

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