The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.

The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Research Abstract Details 

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The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Abstract Text:

Vyacheslav M Labunskyy,Dolph L Hatfield,Vadim N Gladyshev,

Disulfide bonds play an important role in the structure and function of membrane and secretory proteins. The formation of disulfide bonds in the endoplasmic reticulum (ER) of eukaryotic cells is catalyzed by a complex network of thiol-disulfide oxidoreductases. Whereas a number of ER-resident oxidoreductases have been identified, the function of only a few of them is firmly established. Recently, a selenocysteine-containing oxidoreductase, Sep15, has been implicated in disulfide bond assisted protein folding, and a role in quality control for this selenoprotein has been proposed. This review summarizes up-to-date information on the Sep15 family proteins and highlights new insights into their physiological function.

The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Publishing Authors By Initials

VM Labunskyy,DL Hatfield,VN Gladyshev,

For similar proteins: selenoproteins research abstracts see: proteins: selenoproteins research

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The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Journal Published:

PUBLICATION TYPE: Review

Journal: IUBMB life

VOLUME: 59

Page Numbers: 1-5

Journal Abbreviation: IUBMB Life

ISSN: 1521-6543

DAY: 3

MONTH: Jan

YEAR: 2007

The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Information

Number of References: 30

LANGUAGE: eng

NlmUniqueID: 100888706

The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Keywords Mesh Terms:

KEYWORDS: Selenoproteins

MESH TERMS: physiology

Chemical & Substance for Abstract: The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. Information

Substance Name: Protein Disulfide Reductase (Glutathione

Registry Number: EC 1.8.4.2

Grant and Affiliation Information for The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.

AFFILIATION: Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.

Country: England

AGENCY: United States NCI

GRANT: CA 080946

ACRONYM: CA

MEDLINETA: IUBMB Life

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