The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.

The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Research Abstract Details 

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The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Abstract Text:

Peter R Hoffmann,Simone C ,Ping-An Li,Fukun W Hoffmann,Ann C Hashimoto,Marla J Berry,

Selenoprotein P (Sel P) is a selenium-rich glycoprotein believed to play a key role in selenium (Se) transport throughout the body. Development of a Sel P knockout mouse model has supported this notion and initial studies have indicated that selenium supply to various tissues is differentially affected by genetic deletion of Sel P. Se in the form of the amino acid, selenocysteine, is incorporated into selenoproteins at UGA codons. Thus, Se availability affects not only selenoprotein levels, but also the turnover of selenoprotein mRNAs via the nonsense-mediated decay pathway. We investigated how genetic deletion of Sel P in mice affected levels of the mRNAs encoding all known members of the murine selenoprotein family, as well as three non-selenoprotein factors involved in their synthesis, selenophosphate synthetase 1 (SPS1), SECIS-binding protein 2 (SBP2) and SECp43. Our findings present a comprehensive description of selenoprotein mRNA expression in the following murine tissues: brain, heart, intestine, kidney, liver, lung, spleen and testes. We also describe how abundance of selenoproteins and selenoprotein-synthesis factors are affected by genetic deletion of Sel P in some of these tissues, providing insight into how the presence of this selenoprotein influences selenoprotein mRNA levels, and thus, the selenoproteome.

The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Publishing Authors By Initials

PR Hoffmann,SC ,PA Li,FW Hoffmann,AC Hashimoto,MJ Berry,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: 3963-73

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 6

MONTH: 06

YEAR: 2007

The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Information

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LANGUAGE: eng

NlmUniqueID: 411011

The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: metabolism

Chemical & Substance for Abstract: The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Information

Substance Name: Selenium

Registry Number: 7782-49-2

Grant and Affiliation Information for The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply.

AFFILIATION: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. peterh@pbrc.hawaii.edu

Country: England

AGENCY: United States NINDS

GRANT: R01 NS40302

ACRONYM: NS

MEDLINETA: Nucleic Acids Res

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