The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.

The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Research Abstract Details 

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The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Abstract Text:

Dong Hyun Kim,Byung Hoon Yoon,Yong-Won Kim,Seungjoo Lee,Bum Young Shin,Ji Wook Jung,Hyoung Ja Kim,Yong Sup Lee,Jae Sue Choi,Sun Yeou Kim,Kyung-Tae Lee,Jong Hoon Ryu,Dong Hyun Kim,Byung Hoon Yoon,Yong-Won Kim,Seungjoo Lee,Bum Young Shin,Ji Wook Jung,Hyoung Ja Kim,Yong Sup Lee,Jae Sue Choi,Sun Yeou Kim,Kyung-Tae Lee,Jong Hoon Ryu,

In the present study, we assessed the effect of the ethanolic extract of the seeds of Cassia obtusifolia (COE) on the learning and memory impairments induced by scopolamine or transient bilateral common carotid artery occlusion (2VO). In a study of the cholinergic dysfunction induced by scopolamine, single COE (25, 50, or 100 mg/kg, p.o.) administration significantly attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks (P<0.05) and also reduced escape-latency on the Morris water maze task (P<0.05). In the 2VO study, COE (50 mg/kg, p.o.) significantly reversed 2VO-induced cognitive impairments in mice by the passive avoidance and the Y-maze tasks (P<0.05). Moreover, COE (50 mg/kg, p.o.) also reduced escape-latency and prolonged swimming time in the target quadrant during a probe trial of the Morris water maze task (P<0.05). In an in vitro study, COE was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50) value: 81.6 microg/ml). Furthermore, COE also inhibited acetylcholinesterase activity in an ex vivo study. These results suggest that COE attenuates memory impairment induced by scopolamine or 2VO and that these effects are mediated by enhancing the cholinergic nervous system via acetylcholinesterase inhibition.

The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Publishing Authors By Initials

DH Kim,BH Yoon,YW Kim,S Lee,BY Shin,JW Jung,HJ Kim,YS Lee,JS Choi,SY Kim,KT Lee,JH Ryu,DH Kim,BH Yoon,YW Kim,S Lee,BY Shin,JW Jung,HJ Kim,YS Lee,JS Choi,SY Kim,KT Lee,JH Ryu,

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The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmacological sciences

VOLUME: 105

Page Numbers: 82-93

Journal Abbreviation: J. Pharmacol. Sci.

ISSN: 1347-8613

DAY: 26

MONTH: Sep

YEAR: 2007

The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. Information

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LANGUAGE: eng

NlmUniqueID: 101167001

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Grant and Affiliation Information for The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.

AFFILIATION: Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Korea.

Country: Japan

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MEDLINETA: J Pharmacol Sci

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