The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs.

The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Research Abstract Details 

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The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Abstract Text:

Most drugs are prescribed for several illnesses, but it took several years for psychotropic drugs to have multiple clinical indications. Our search for serotonergic drugs in affective illnesses and related disorders led to new off-label indications for fluoxetine, sertraline, tryptophan, clonazepam, alprazolam, tomoxetine, buproprion, duloxetine, risperidone and gabapentin. Various clinical trial designs were used for these proof-of-concept studies. Novel therapeutic uses of benzodiazepines, such as in panic disorder and mania, were found with the introduction of 2 high-potency benzodiazepines, clonazepam and alprazolam, which were thought to have serotonergic properties. Our initial clinical trials of fluoxetine and sertraline led to their approved indications in the treatment of obsessive-compulsive disorder, and our trials of gabapentin led to new indications in anxiety disorders (generalized anxiety, panic attack and social phobia) and sleep disorders (insomnia).

The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Publishing Authors By Initials

For similar mental disorders research abstracts see: mental disorders research

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The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 31

Page Numbers: 168-76

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: May

YEAR: 2006

The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Information

Number of References: 112

LANGUAGE: eng

NlmUniqueID: 9107859

The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Keywords Mesh Terms:

KEYWORDS: Mental Disorders

MESH TERMS: psychology

Chemical & Substance for Abstract: The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Information

Substance Name: Antipsychotic Agents

Registry Number: 0

Grant and Affiliation Information for The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs.

AFFILIATION: Clinical Psychopharmacology Unit, Allan Memorial Institute, McGill University Health Centre, McGill University, Montréal, Que, Canada. va.chouinard@gmail.com

Country: Canada

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MEDLINETA: J Psychiatry Neurosci

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