The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba.

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Abstract Text:

OBJECTIVE: To assess the safety and efficacy of the 308-nm excimer laser in pigment correction of hypopigmented scars and striae alba. DESIGN: Institutional review board-approved randomized controlled trial. SETTING: Private research center. PATIENTS: Volunteer sample of 31 adult subjects with hypopigmented scars or striae alba distributed on the face, torso, or extremities. INTERVENTIONS: Lesions were randomized to receive treatment or not, with site-matched normal control areas. Treatments were initiated with a minimal erythema dose minus 50 mJ/cm(2) to affected areas. Subsequent treatments were performed biweekly until 50% to 75% pigment correction, then every 2 weeks thereafter until a maximum of 10 treatments, 75% increase in colorimetric measurements, or 100% visual pigment correction. MAIN OUTCOME MEASURES: Pigment correction by visual and colorimetric assessments compared with untreated control lesions and site-matched normal skin before each treatment and at 1-, 2-, 4-, and 6-month follow-up intervals. Occurrence of erythema, blistering, dyspigmentation, or other adverse effects was monitored. RESULTS: The percentage pigment correction by both assessments increased in direct proportion to the number of treatments. The mean percentage pigment correction by visual assessment relative to control of 61% (95% confidence interval [CI], 55%-67%) for scars and 68% (95% CI, 62%-74%) for striae was achieved after 9 treatments. The mean percentage pigmentation by colorimetric measurements relative to control of 101% (95% CI, 99%-103%) for scars and 102% (95% CI, 99%-104%) for striae was achieved after 9 treatments. Both sets of values gradually declined toward baseline levels during the 6-month follow-up. No blistering or dyspigmentation occurred. CONCLUSIONS: Therapy with the 308-nm excimer laser is safe and effective in pigment correction of hypopigmented scars and striae alba. Mean final pigment correction rates relative to control sites of approximately 60% to 70% by visual assessment and 100% by colorimetric analysis were observed after 9 treatments administered biweekly. Maintenance treatment every 1 to 4 months is required to sustain the cosmetic benefit.

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Publishing Authors By Initials

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

PUBMED ID PMID:

MEDLINE DATE:

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of dermatology

VOLUME: 140

Page Numbers: 955-60

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Aug

YEAR: 2004

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: radiotherapy

Chemical & Substance for Abstract: The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba.

AFFILIATION: Laser & Skin Surgery Center of New York, NY, USA. dralexiades@nyderm.org

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Dermatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba Related Publications

• Anatomical differences of port-wine stains in response to treatment with the pulsed dye laser.
• Arteriovenous malformation treated with embolization and laser therapy.
• Basal cell carcinoma arising 57 years after interstitial radiotherapy of a nasal hemangioma.
• Capillary hemangiomas and treatment with the flash lamp-pumped pulsed dye laser.
• Deep venous thrombosis following Mohs micrographic surgery: case report.
• Detection of human papillomavirus DNA in squamous cell carcinoma of the nail bed and finger determined by polymerase chain reaction.
• Efficacy of early treatment of facial port wine stains in newborns: a review of 49 cases.
• Lack of efficacy of the Q-switched ruby laser in the treatment of vitiligo.
• Laser-mediated photodynamic therapy of actinic keratoses.
• Poikiloderma of civatte.
• Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing.
• The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba.
• Thrombocytopenia-absent radii syndrome and lack of response to the pulsed dye laser.
• Treatment of nasolabial folds and jowls with a noninvasive radiofrequency device.
• Treatment of small and medium congenital nevi with the Q-switched ruby laser.
• Ultraviolet-laser ablation of skin.
• Use of the 308-nm excimer laser for postresurfacing leukoderma.