The role of Wnts in bone metastases.

The role of Wnts in bone metastases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of Wnts in bone metastases. Abstract Text:

Christopher L Hall,Evan T Keller,

Wnts are a large family of secreted glycoproteins that mediate bone development in the embryo and promote bone production in the adult. Autocrine Wnt signaling within tumor cells has been shown to promote tumorigenesis by enhancing tumor cell proliferation and survival. We recently demonstrated that prostate cancer cells (CaP) produce Wnts which act in a paracrine fashion to induce osteoblastic activity in CaP bone metastases. The ability of tumor-derived Wnts to influence bone development is regulated by multiple families of secreted antagonists including soluble frizzled related receptors (sFrp) and dickkopfs (DKK). CaP cells appear to produce DKK-1 early in the development of skeletal metastases, which masks osteogenic Wnts and thus favors an osteolytic environment at the metastatic site. As the metastases progresses, DKK-1 expression is lost allowing for a Wnt mediated osteoblastic response which predominates CaP boney lesions. Interestingly, blocking DKK-1 expression early in CaP metastasis prevents tumor establishment within the bone suggesting that osteolysis is a required first step in the development of CaP bone metastases. In this review, we discuss our data on the Wnt inhibitor DKK-1 in CaP bone metastasis in the context of current literature evidence that demonstrate that Wnt inhibitors can function as both tumor suppressors and tumor promoters. We provide a model that the affect of Wnt inhibitors on tumor development is dependent on the tumor micro-environment and suggest that DKK-1 is a switch which transitions CaP bone metastases from osteolytic to osteoblastic.

The role of Wnts in bone metastases. Publishing Authors By Initials

CL Hall,ET Keller,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

PUBMED ID PMID:

MEDLINE DATE:

The role of Wnts in bone metastases. Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer metastasis reviews

VOLUME: 25

Page Numbers: 551-8

Journal Abbreviation: Cancer Metastasis Rev.

ISSN: 0167-7659

DAY: 3

MONTH: Dec

YEAR: 2006

The role of Wnts in bone metastases. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 8605731

The role of Wnts in bone metastases. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: The role of Wnts in bone metastases. Information

Substance Name: Wnt Proteins

Registry Number: 0

Grant and Affiliation Information for The role of Wnts in bone metastases.

AFFILIATION: Department of Urology, The University of Michigan, RM 5304 CCGCB, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0940, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: R01 CA071672

ACRONYM: CA

MEDLINETA: Cancer Metastasis Rev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of Wnts in bone metastases Related Publications

• A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates.
• Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.
• Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management.
• BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
• Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.
• Candicine from Stapelia gigantea.
• Children's skin conductance reactivity as a mechanism of risk in the context of parental depressive symptoms.
• Comparison of extracellular and intracellular potency of botulinum neurotoxins.
• Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
• Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
• Drosophila melanogaster's history as a human commensal.
• Effect of glucocorticoid-induced osteoporotic-like conditions on osteoblast cell attachment to implant surface microtopographies.
• Effect of operational parameters on the recovery rate of an oleophilic drum skimmer.
• Flagellar elongation and gene expression in Chlamydomonas reinhardtii.
• GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.
• Illegitimate recombination is a major evolutionary mechanism for initiating size variation in plant resistance genes.
• Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease.
• Metabolic pathway engineering in cotton: Biosynthesis of polyhydroxybutyrate in fiber cells.
• Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
• Production of targeted poly(3-hydroxyalkanoates) copolymers by glycogen accumulating organisms using acetate as sole carbon source.
• Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.
• Reproductive isolation between Pogonomyrmex rugosus and two lineages with genetic caste determination.
• Secondary metabolic gene cluster silencing in Aspergillus nidulans.
• Short telomeres in short-lived males: what are the molecular and evolutionary causes?
• The presumptive floor plate (notoplate) induces behaviors associated with convergent extension in medial but not lateral neural plate cells of Xenopus.
• The role of Wnts in bone metastases.
• The whisking rhythm generator: a novel mammalian network for the generation of movement.
• Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.
• What impact, if any, has feminism had on science?
• [Extraction of thermolabile compounds with supercritical gases.]