The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production.

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Abstract Text:

Kai Soo Tan,Li Qian,Roy Rosado,Patrick M Flood,Lyndon F Cooper,

A role for monocyte/macrophage modulation of wound healing at endosseous implants is proposed. The modification of the endosseous implant surface topography can alter cell adhesion and resultant cell behavior. The aim of this study was to define the effect of increased cpTitanium surface topography on adherent J744A.1 macrophage phenotype in culture. The J744A.1 cells were cultured on 20mm diameter cpTitanium disks prepared with smooth and grit-blasted/acid rough surface topographies for 24-72 h. Following culture in growth media with or without lipopolysaccharide (LPS), total RNA was isolated and real-time polymerase chain reaction (PCR) was used to measure the steady-state levels of the pro-inflammatory cytokines interleukin 1-beta (IL-1beta) and interleukin 6 (IL-6) and the anti-inflammatory cytokine interleukin-10 (IL-10). Additional evidence of pro-inflammatory signaling was sought by measurement of cellular nitric oxide (NO) production. In the absence of LPS, IL-1beta levels were increased on grit-blasted/acid rough surfaces during the first 48 h. In contrast, IL-6 levels were reduced on the grit-blasted/acid rough surfaces. When cultures were treated with LPS, high levels of IL-1beta and IL-6 expression were measured, irrespective of surface topography. The responses of J744A.1 cells to surface and superimposed LPS stimulation suggest only modest effects of the modeled endosseous implant surface on adherent cell pro-inflammatory cytokine expression and NO signaling.

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Publishing Authors By Initials

KS Tan,L Qian,R Rosado,PM Flood,LF Cooper,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biomaterials

VOLUME: 27

Page Numbers: 5170-7

Journal Abbreviation:

ISSN: 0142-9612

DAY: 30

MONTH: 06

YEAR: 2006

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100316

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production.

AFFILIATION: Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, 404 Brauer Hall, CB #7450, Chapel Hill, NC 27511, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biomaterials

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of titanium surface topography on J774A1 macrophage inflammatory cytokines and nitric oxide production Related Publications

• A bichromatic fluorescent reporter for cell-based screens of alternative splicing.
• A classical likelihood based approach for admixture mapping using EM algorithm.
• Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators.
• Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end.
• Body fat and circulating leukocytes in children.
• CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.
• Colorectal cancer screening in the elderly population: disparities by dual Medicare-Medicaid enrollment status.
• Do circulating leucocytes and lymphocyte subtypes increase in response to brief exercise in children with and without asthma?
• Effect of rhIL-6 infusion on GH-->IGF-I axis mediators in humans.
• Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD.
• Evaluation of daily home spirometry for school children with asthma: new insights.
• Identification of prognostic signatures in breast cancer microarray data using Bayesian techniques.
• Issues in maintenance and repairs of wheelchairs: A pilot study.
• LINE-1 Endonuclease-Dependent Retrotranspositional Events Causing Human Genetic Disease: Mutation Detection Bias and Multiple Mechanisms of Target Gene Disruption.
• Lymphoid reconstruction and vaccines.
• Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2.
• Measurement of some novel concepts in psychiatry.
• Patient-specific models for predicting the outcomes of patients with community acquired pneumonia.
• Primitive hematopoietic cell populations reside in the spleen: Studies in the pig, baboon, and human.
• Progress in xenotransplantation following the introduction of gene-knockout technology.
• Quantification of small molecule-receptor affinities and kinetics by acoustic profiling.
• Regional Strength in CAM.
• Regulation of DNA synthesis in bacteria: Analysis of the Bates/Kleckner licensing/initiation-mass model for cell cycle control.
• Shoulder joint kinetics and pathology in manual wheelchair users.
• Stem Cells and CAM.
• The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks.
• The impact of FSANZ labelling changes on knowledge of nutrition and allergens by consumer's, health professional's and allergen sufferers.
• The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production.
• Titanium surface topography alters cell shape and modulates bone morphogenetic protein 2 expression in the J774A.1 macrophage cell line.
• eCAM: On To Year 4.