The role of the orbitofrontal cortex in anxiety disorders.

The role of the orbitofrontal cortex in anxiety disorders. Research Abstract Details 

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The role of the orbitofrontal cortex in anxiety disorders. Abstract Text:

Mohammed R Milad,Scott L Rauch,Mohammed R Milad,Scott L Rauch,Mohammed R Milad,Scott L Rauch,

Advances in neuroimaging techniques over the past two decades have allowed scientists to investigate the neurocircuitry of anxiety disorders. Such research has implicated the orbitofrontal cortex (OFC). Characterizing the role of OFC in anxiety disorders, however, is principally complicated by two factors-differences in underlying pathophysiology across the anxiety disorders and heterogeneity in function across different OFC sub-territories. Contemporary neurocircuitry models of anxiety disorders have primarily focused on amygdalo-cortical interactions. The amygdala is implicated in generating fear responses, whereas cortical regions, specifically the medial OFC (mOFC) and the ventromedial prefrontal cortex (vmPFC), are implicated in fear extinction. In contrast to mOFC, anterolateral OFC (lOFC) has been associated with negative affects and obsessions and thus dysfunctional lOFC may underlie different aspects of certain anxiety disorders. Herein, we aim to review the above-mentioned theories and provide a heuristic model for conceptualizing the respective roles of mOFC and lOFC in the pathophysiology and treatment of anxiety disorders. We will also review the role of the OFC in fear extinction and the implications of this role to the pathophysiology of anxiety disorders.

The role of the orbitofrontal cortex in anxiety disorders. Publishing Authors By Initials

MR Milad,SL Rauch,MR Milad,SL Rauch,MR Milad,SL Rauch,

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The role of the orbitofrontal cortex in anxiety disorders. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1121

Page Numbers: 546-61

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 14

MONTH: 08

YEAR: 2007

The role of the orbitofrontal cortex in anxiety disorders. Information

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LANGUAGE: eng

NlmUniqueID: 7506858

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AFFILIATION: Department of Psychiatry, Massachusetts General Hospital, Bldg 149, 13th Street, 2nd Floor, Charlestown, MA 02129. milad@nmr.mgh.harvard.edu.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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