The role of the collagen matrix in skeletal fragility.

The role of the collagen matrix in skeletal fragility. Research Abstract Details 

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The role of the collagen matrix in skeletal fragility. Abstract Text:

Deepak Vashishth,

The collagen network in bone provides resistance against fracture and may be susceptible to changes with aging and disease. This review identifies the changes in quality of collagen matrix as contributors to bone fragility. With aging and in diabetes, cross-links accumulate in bone collagen as a result of nonenzymatic glycation and consequently impair matrix properties, increasing bone fragility. Cell-culture and animal studies suggest that the accumulation of cross-links induced by nonenzymatic glycation may be related to a reduction in bone turnover resulting from the altered responses of osteoblasts and osteoclasts to advanced glycation end products.

The role of the collagen matrix in skeletal fragility. Publishing Authors By Initials

D Vashishth,

For similar musculoskeletal system: skeleton research abstracts see: musculoskeletal system: skeleton research

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The role of the collagen matrix in skeletal fragility. Journal Published:

PUBLICATION TYPE: Review

Journal: Current osteoporosis reports

VOLUME: 5

Page Numbers: 62-6

Journal Abbreviation:

ISSN: 1544-1873

DAY: 3

MONTH: Jun

YEAR: 2007

The role of the collagen matrix in skeletal fragility. Information

Number of References: 49

LANGUAGE: eng

NlmUniqueID: 101176492

The role of the collagen matrix in skeletal fragility. Keywords Mesh Terms:

KEYWORDS: Skeleton

MESH TERMS: physiology

Chemical & Substance for Abstract: The role of the collagen matrix in skeletal fragility. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for The role of the collagen matrix in skeletal fragility.

AFFILIATION: Center of Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. vashid@rpi.edu

Country: United States

AGENCY: United States NIA

GRANT: R01 AG020618-02

ACRONYM: AG

MEDLINETA: Curr Osteoporos Rep

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