The role of the beta-glucan receptor Dectin-1 in control of fungal infection.

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Abstract Text:

Kevin M Dennehy,Gordon D Brown,

During fungal infection, a variety of receptors initiates immune responses, including TLR and the beta-glucan receptor Dectin-1. TLR recognition of fungal ligands and subsequent signaling through the MyD88 pathway were thought to be the most important interactions required for the control of fungal infection. However, recent papers have challenged this view, highlighting the role of Dectin-1 in induction of cytokine responses and the respiratory burst. Two papers, using independently derived, Dectin-1-deficient mice, address the role of Dectin-1 in control of fungal infection. Saijo et al. [1] argue that Dectin-1 plays a minor role in control of Pneumocystis carinii by direct killing and that TLR-mediated cytokine production controls P. carinii and Candida albicans. By contrast, Taylor et al. [2] argue that Dectin-1-mediated cytokine and chemokine production, leading to efficient recruitment of inflammatory cells, is required for control of fungal infection. In this review, we argue that collaborative responses induced during infection may partially explain these apparently contradictory results. We propose that Dectin-1 is the first of many pattern recognition receptors that can mediate their own signaling, as well as synergize with TLR to initiate specific responses to infectious agents.

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Publishing Authors By Initials

KM Dennehy,GD Brown,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic research

PUBMED ID PMID:

MEDLINE DATE:

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 253-8

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 2

MONTH: 05

YEAR: 2007

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8405628

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Keywords Mesh Terms:

KEYWORDS: Receptors, Immunologic

MESH TERMS: metabolism

Chemical & Substance for Abstract: The role of the beta-glucan receptor Dectin-1 in control of fungal infection. Information

Substance Name: dectin 1

Registry Number: 0

Grant and Affiliation Information for The role of the beta-glucan receptor Dectin-1 in control of fungal infection.

AFFILIATION: Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Country: United States

AGENCY: United Kingdom Wellcome T

GRANT: 1R01HL080317

ACRONYM: HL

MEDLINETA: J Leukoc Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of the beta-glucan receptor Dectin-1 in control of fungal infection Related Publications

• A radioimmunoassay method for the determination of nedocromil sodium in plasma and urine.
• ABCB1 2677G>T/A genotype and paclitaxel pharmacogenetics in ovarian cancer.
• Age-related macular degeneration: self-management and reduction of depressive symptoms in a randomized, controlled study.
• Application of item response theory to quantify substance use disorder severity.
• Cell structure and mobilization of lipids and proteins from cotyledon under microgravity influence.
• Chemokine receptors : therapeutic potential in asthma.
• Circadian rhythms. Chronobiology--reducing time.
• Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells.
• Effect of gonadotrophin releasing hormone on conception rate in repeat-breeder dairy cows.
• Engineered iron oxide-adhesion mutants of the Escherichia coli phage lambda receptor.
• Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression.
• From tip-of-the-tongue (TOT) data to theoretical implications in two steps: when more TOTs means better retrieval.
• Gravisensing: ionic responses, cytoskeleton and amyloplast behavior.
• Identifying housing that poisons: a critical step in eliminating childhood lead poisoning.
• Impaired trace and contextual fear conditioning in aged rats.
• In vivo metabolism of alpha-tocopherol in lipoproteins and liver: studies on rabbits in response to acute cholesterol loading.
• LIPID arrays: new tools in the understanding of membrane dynamics and lipid signaling.
• Loading and boundary condition influences in a poroelastic finite element model of cartilage stresses in a triaxial compression bioreactor.
• Meta-analysis of the effect of exercise interventions on fitness outcomes among adults with type 1 and type 2 diabetes.
• Prenatal diagnostic testing for infantile and late-infantile neuronal ceroid lipofusinoses (NCL) using allele specific primer extension (ASPE).
• Quantitative analysis reveals differential expression of mucin (MUC2) and intestinal trefoil factor mRNAs along the longitudinal axis of rat intestine.
• RHO SIGNALING in vascular diseases.
• Regio- and stereoselective glycosylation: synthesis of 5-haloimidazole alpha-ribonucleosides.
• Solid-state 2H NMR structure of retinal in metarhodopsin I.
• Spermagglutinins in serum and seminal fluid of bulls and their relationship to fertility classification.
• Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha.
• Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology.
• Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells.
• Treatment of the severe refractory irritable bowel patient.
• Working with a Head Start population with asthma: lessons learned.