The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action.

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Abstract Text:

The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins. However, recent cloning of the two subunits of the DNA-binding form of the AH receptor has shown that this is not the case. These subunits, the AH receptor nuclear translocator protein (ARNT) and the ligand-binding AH receptor monomer, do not contain zinc finger DNA-binding domains, nor do they have any other sequence similarities with members of the above family. Instead, they both contain basic helix-loop-helix (bHLH) motifs and also another segment of sequence similarity, the "PAS" region. bHLH motifs in other transcription factors are known to function as dimerization and DNA-binding domains. Present experiments are directed toward understanding the mechanisms of action and the roles of the two subunits.

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in endocrinology and metabolism: TEM

VOLUME: 5

Page Numbers: 240-4

Journal Abbreviation: Trends Endocrinol. Metab.

ISSN: 1043-2760

DAY: 14

MONTH: Aug

YEAR: 1994

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9001516

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action.

AFFILIATION: The Department of Pathology and Laboratory Medicine, and Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, CA 90024-1786, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Trends Endocrinol Metab

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action Related Publications

• A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.
• A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.
• A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer.
• A prospective study of postmenopausal hormone use and ovarian cancer risk.
• Aspirin, NSAID, and Acetaminophen Use and the Risk of Endometrial Cancer.
• Association of activity and chronic disease risk factors: utility and limitations of objectively measured physical activity data.
• Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk.
• Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women.
• Body shape throughout life and correlations with IGFs and GH.
• Breastfeeding and risk of ovarian cancer in two prospective cohorts.
• Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer.
• Circulating colony stimulating factor-1 and breast cancer risk.
• Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women.
• Circulating levels of sex steroids and prolactin in premenopausal women and risk of breast cancer.
• Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women.
• Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women.
• Identification of novel dioxin-responsive genes by representational difference analysis.
• Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis.
• Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts.
• Menopausal and reproductive factors and risk of age-related macular degeneration.
• Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones.
• Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer.
• Plasma adiponectin concentrations and risk of incident breast cancer.
• Plasma androgen concentrations and risk of incident ovarian cancer.
• Prolactin and breast cancer risk.
• Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.
• Reproducibility of proteomic profiles over 3 years in postmenopausal women not taking postmenopausal hormones.
• The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action.
• Use of biomarkers in epidemiologic studies: minimizing the influence of measurement error in the study design and analysis.
• Why does ARNT2 behave differently from ARNT?