The role of syndecans in disease and wound healing.

The role of syndecans in disease and wound healing. Research Abstract Details 

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The role of syndecans in disease and wound healing. Abstract Text:

Constance Y Fears,Anne Woods,

Syndecans are a family of transmembrane heparan sulfate proteoglycans widely expressed in both developing and adult tissues. Until recently, their role in pathogenesis was largely unexplored. In this review, we discuss the reported involvement of syndecans in human cancers, infectious diseases, obesity, wound healing and angiogenesis. In some cancers, syndecan expression has been shown to regulate tumor cell function (e.g. proliferation, adhesion, and motility) and serve as a prognostic marker for tumor progression and patient survival. The ectodomains and heparan sulfate glycosaminoglycan chains of syndecans can also act as receptors/co-receptors for some bacterial and viral pathogens, mediating infection. In addition, syndecans bind to obesity-related factors and regulate their signaling, in turn modulating food consumption and weight balance. In vivo animal models of tissue injury and in vitro data also implicate syndecans in processes necessary for wound healing, including fibroblast and endothelial proliferation, cell motility, angiogenesis, and extracellular matrix organization. These new insights into the involvement of syndecans in disease and tissue repair coupled with the emergence of syndecan-specific molecular tools may lead to novel therapies for a variety of human diseases.

The role of syndecans in disease and wound healing. Publishing Authors By Initials

CY Fears,A Woods,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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The role of syndecans in disease and wound healing. Journal Published:

PUBLICATION TYPE: Review

Journal: Matrix biology : journal of the International Soci

VOLUME: 25

Page Numbers: 443-56

Journal Abbreviation: Matrix Biol.

ISSN: 0945-053X

DAY: 14

MONTH: 07

YEAR: 2006

The role of syndecans in disease and wound healing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432592

The role of syndecans in disease and wound healing. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: physiology

Chemical & Substance for Abstract: The role of syndecans in disease and wound healing. Information

Substance Name: Syndecans

Registry Number: 0

Grant and Affiliation Information for The role of syndecans in disease and wound healing.

AFFILIATION: The Department of Cell Biology, University of Alabama at Birmingham 35294, United States.

Country: Germany

AGENCY: United States NHLBI

GRANT: T32-HL07918

ACRONYM: HL

MEDLINETA: Matrix Biol

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