The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament.

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Abstract Text:

Christl Reisenauer,Thomas Shiozawa,Matthias Oppitz,Christian Busch,Andreas Kirschniak,Tanja Fehm,Ulrich Drews,Christl Reisenauer,Thomas Shiozawa,Matthias Oppitz,Christian Busch,Andreas Kirschniak,Tanja Fehm,Ulrich Drews,

The uterosacral ligament (USL) is part of the pelvic floor connecting the uterus to the dorsal body wall and stabilizing it. In samples obtained from hysterectomy patients, the smooth muscle component of the cervical third of the USL was studied by smooth muscle actin (SMA) immunohistochemistry as indicator for structural abnormalities and by morphometric determination of nuclear size as measure for the functional state. From a total of 40 patients, 18 were matched according to age, parity, and premenopausal status. Immunohistochemistry showed a granular patchy distribution of SMA in the pelvic organ prolapse (POP) group. In patients with POP, the size of smooth muscle cell nuclei was significantly reduced in comparison to patients without POP (25.45 +/- 1.92 mum(2) vs 28.87 +/- 2.92 mum(2), p < 0.05). We conclude that the smooth muscle component of the USL is impaired in POP patients, indicating a possible role of smooth muscle in the pathogenesis of POP.

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Publishing Authors By Initials

C Reisenauer,T Shiozawa,M Oppitz,C Busch,A Kirschniak,T Fehm,U Drews,C Reisenauer,T Shiozawa,M Oppitz,C Busch,A Kirschniak,T Fehm,U Drews,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International urogynecology journal and pelvic flo

VOLUME: 19

Page Numbers: 383-9

Journal Abbreviation:

ISSN: 0937-3462

DAY: 2

MONTH: 10

YEAR: 2007

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9514583

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament.

AFFILIATION: Department of Obstetrics and Gynecology, University of Tuebingen, Calwerstr. 7, 72076, Tuebingen, Germany, christl.reisenauer@med.uni-tuebingen.de.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int Urogynecol J Pelvic Floor

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament Related Publications

• A finer cup forceps on a colibri handle.
• A lens implant holder.
• A micro iris retractor.
• A new ceiling mount for Zeiss operating microscopes.
• A reordered Rekoss disc.
• A self-retaining iris retractor.
• AGL61 Interacts with AGL80 and Is Required for Central Cell Development in Arabidopsis.
• An adenylate kinase is involved in K(ATP) channel regulation of mouse pancreatic beta cells.
• Assessing data quality in manual entry of ventilator settings.
• Gene technology and the drugs of tomorrow.
• Helper function of the wolffian ducts and role of androgens in the development of the vagina.
• Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas.
• MYB98 positively regulates a battery of synergid-expressed genes encoding filiform apparatus localized proteins.
• Recent advances in ophthalmology.
• Reliability of MR imaging-based virtual cystoscopy in the diagnosis of cancer of the urinary bladder.
• Synergid cell death in Arabidopsis is triggered following direct interaction with the pollen tube.
• The AGL62 MADS Domain Protein Regulates Cellularization during Endosperm Development in Arabidopsis.
• The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells.
• The MYB98 subcircuit of the synergid gene regulatory network includes genes directly and indirectly regulated by MYB98.
• The pharmacology of the immune system: clinical and experimental perspectives.
• The role of smooth muscle in the pathogenesis of pelvic organ prolapse-an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament.
• [A new local antibiotic in the treatment of dermatological affections.]
• [Calcium metabolism in patients with peptic ulcer of the jejunum]
• [Case of early liver cirrhosis associated with post-traumatic splenic cyst]
• [Cholinesterase activity during the formation and resolution of the somites in chick embryo]
• [Genetic background of preeclampsia]
• [On the activity of esterases, in particular cholinesterase, in the adrenal gland region in rats during fetal development]
• [Selected blood clotting factors in surgically treated patients at an early post-surgery stage]
• [Significance of early diagnosis of cancer of the stomach and of the esophagus in surgical therapy.]
• [Treatment of cancer of the colon.]