The role of small molecule inhibitors for veterinary patients.

The role of small molecule inhibitors for veterinary patients. Research Abstract Details 

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The role of small molecule inhibitors for veterinary patients. Abstract Text:

Cheryl A London,Cheryl A London,Cheryl A London,

Advances in molecular biology over the past several years have permitted a much more detailed understanding of cellular dysfunction at the biochemical level in cancer cells. This has resulted in the identification of novel targets for therapeutic intervention, including proteins that regulate signal transduction, gene expression, and protein turnover. In many instances, small molecules are used to disrupt the function of these targets, often through competitive inhibition of ATP binding or the prevention of necessary protein-protein interactions. Future challenges lie in identifying appropriate targets for intervention and combining small molecule inhibitors with standard treatment modalities, such as radiation therapy and chemotherapy.

The role of small molecule inhibitors for veterinary patients. Publishing Authors By Initials

CA London,CA London,CA London,

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PUBLICATION TYPE: Journal Article

Journal: The Veterinary clinics of North America. Small ani

VOLUME: 37

Page Numbers: 1121-36

Journal Abbreviation: Vet. Clin. North Am. Small Ani

ISSN: 0195-5616

DAY: 22

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 454 VMAB, 1925 Coffey Road, Columbus, OH 43210, USA.

Country: United States

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MEDLINETA: Vet Clin North Am Small Anim P

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