The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy.

The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy. Research Abstract Details 

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The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy. Abstract Text:

Qing Zhang,Jeffrey Wing-Hong Fung,Yat-Sun Chan,Hamish Chi-Kin Chan,Hong Lin,Skiva Chan,Cheuk-Man Yu,

BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective therapy for heart failure patients with electromechanical delay. Optimization of atrioventricular interval (AVI) is a cardinal component for the benefits. However, it is unknown if the AVI needs to be re-optimized during long-term follow-up. METHODS: Thirty-one patients (66+/-11 years, 20 males) with sinus rhythm who received CRT underwent serial optimization of AVI at day 1, 3-month and during long-term follow-up by pulse Doppler echocardiography (PDE). At long-term follow-up, the optimal AVI and cardiac output (CO) estimated by non-invasive impedance cardiography (ICG) were compared with those by PDE. RESULTS: The follow-up was 16+/-11 months. There was no significant difference in the mean optimal AVI when compared between any 2 time points among day 1 (99+/-30 ms), 3-month (97+/-28 ms) and long-term follow-up (94+/-28 ms). However, in individual patient, the optimal AVI remained unchanged only in 14 patients (44%), and was shortened in 12 (38%) and lengthened in 6 patients (18%). During long-term follow-up, although the mean optimal AVIs obtained by PDE or ICG (94+/-28 vs. 92+/-29 ms) were not different, a discrepancy was found in 14 patients (45%). For the same AVI, the CO measured by ICG was systematically higher than that by PDE (3.5+/-0.8 Vs. 2.7+/-0.6 L/min, p<0.001). CONCLUSION: Optimization of AVI after CRT appears necessary during follow-up as it was readjusted in 55% of patients. Although AVI optimization by ICG was feasible, further studies are needed to confirm its role in optimizing AVI after CRT.

The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy. Publishing Authors By Initials

Q Zhang,JW Fung,YS Chan,HC Chan,H Lin,S Chan,CM Yu,

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The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of cardiology

VOLUME: 124

Page Numbers: 211-7

Journal Abbreviation: Int. J. Cardiol.

ISSN: 1874-1754

DAY: 17

MONTH: 04

YEAR: 2007

The role of repeating optimization of atrioventricular interval during interim and long-term follow-up after cardiac resynchronization therapy. Information

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LANGUAGE: eng

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AFFILIATION: Division of Cardiology, S.H. Ho Cardiovascular and Stroke Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

Country: Netherlands

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MEDLINETA: Int J Cardiol

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