The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress.

The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Research Abstract Details 

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The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Abstract Text:

K Nakamura,A Aoike,K Rokutan,T Hosokawa,K Koyama,K Kawai,

To investigate the role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced by psychological stress, we exposed 3-mo-old C3H mice to feeding-restriction stress for 1 to 5 days. Serial changes in the activities of antioxidant enzymes in the gastric mucosa, together with O2- production by macrophages, were measured. The stress increased the plasma cortisol level and started to produce acute gastric lesions (AGL) on the 2nd day. Before the development of AGL, the activity of superoxide dismutase in the gastric mucosa had already decreased and the ability of O2- production by macrophages was enhanced from the 1st day. This suggests that oxygen radicals play some role in the development of AGL induced by the stress.

The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Publishing Authors By Initials

K Nakamura,A Aoike,K Rokutan,T Hosokawa,K Koyama,K Kawai,

For similar pathological conditions, signs and symptoms: pathologic processes: stress research abstracts see: pathological conditions, signs and symptoms: pathologic processes: stress research

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The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 162

Page Numbers: 47-50

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1989

The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Information

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LANGUAGE: eng

NlmUniqueID: 437034

The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Keywords Mesh Terms:

KEYWORDS: Stress

MESH TERMS: pathology

Chemical & Substance for Abstract: The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress.

AFFILIATION: Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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