The role of natural killer cells in viral infections.

The role of natural killer cells in viral infections. Research Abstract Details 

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The role of natural killer cells in viral infections. Abstract Text:

Natural killer (NK) cells are important effectors for the lysis of both neoplastic and virus-infected cells. Lectin-like receptors on human NK cells, such as NKR-PIA and CD94, bind to target cell carbohydrate ligands and initiate the lytic process. In addition, P58 and P70 bind to major histocompatibility class I antigens on targets and mediate negative signals. Models using NK cell-deficient mice have proven useful in elaborating the role of NK cells in the immune defence against multiple viral agents. In addition, studies in humans have suggested a vital role of NK cells in the host defence against human immunodeficiency virus, herpesviruses, hepatitis B and C and other viruses. Several genetic disorders, chronic illnesses and infections have been associated with decreased NK function.

The role of natural killer cells in viral infections. Publishing Authors By Initials

For similar virus diseases research abstracts see: virus diseases research

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The role of natural killer cells in viral infections. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of immunology

VOLUME: 46

Page Numbers: 217-24

Journal Abbreviation: Scand. J. Immunol.

ISSN: 0300-9475

DAY: 5

MONTH: Sep

YEAR: 1997

The role of natural killer cells in viral infections. Information

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LANGUAGE: eng

NlmUniqueID: 323767

The role of natural killer cells in viral infections. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: physiopathology

Chemical & Substance for Abstract: The role of natural killer cells in viral infections. Information

Substance Name: Killer Cell Lectin-Like Receptor Subfami

Registry Number: 145113-62-8

Grant and Affiliation Information for The role of natural killer cells in viral infections.

AFFILIATION: UC Irvine Medical Center, Department of Medicine, Orange 92668, USA.

Country: ENGLAND

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MEDLINETA: Scand J Immunol

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