The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting.

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Abstract Text:

Lesli Ann Rawles,Diana Acuna,Robert P Erickson,Lesli Ann Rawles,Diana Acuna,Robert P Erickson,

Previous studies have shown a role for multiple drug resistance proteins in protecting the fetus from a limited number of teratogens. We have expanded the number of proteins and teratogens examined by comparing the influence of the mdr1a and mdr2 proteins on teratogen-induced orofacial clefting using their respective knockouts in crosses with the A/J, high susceptibility strain. Western blots identified the presence of mdr1a and possibly mdr2 in the placenta and fetus. The mdr1a knockout, on its unique genetic background showed lower, similar, and higher incidences of clefting compared to A/J for Dilantin, hydrocortisone (HC), and 6-aminonicotinamide (6-AN), respectively. The mdr2 knockout did not affect 6-AN clefting when compared to A/J. In reciprocal crosses, when corrected for increased spontaneous clefting, maternally inherited A/J susceptibility genes predominated over the effects of the maternal absence of mdr1a (with 6-AN). Unlike mdr1a, which had a direct effect in the fetus as shown by genotyping of affected versus unaffected fetuses, an effect of mdr2 in the fetus was not found. The mdr1a knockout was backcrossed to the A/J inbred strain for 11 generations (congenics) to eliminate genetic background effects. Reciprocal crosses showed no maternal effect from the lack of mdr1a, confirming that mdr1a expression in the fetus, rather than the placenta, protects the fetus from teratogens. Mdr2 seems not to be involved in the protection of the fetus from teratogens.

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Publishing Authors By Initials

LA Rawles,D Acuna,RP Erickson,LA Rawles,D Acuna,RP Erickson,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular reproduction and development

VOLUME: 74

Page Numbers: 1483-9

Journal Abbreviation: Mol. Reprod. Dev.

ISSN: 1040-452X

DAY: 4

MONTH: Nov

YEAR: 2007

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8903333

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting.

AFFILIATION: Angel Charity for Children - Wings for Genetic Research, Steele Children's Research Center, Department of Pediatrics, Section of Medical and Molecular Genetics, University of Arizona, Tucson, Arizona, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: ES 10047

ACRONYM: ES

MEDLINETA: Mol Reprod Dev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting Related Publications

• A comparison of solid and liquid soap as vehicles for G-11, hexachlorophene, in the surgical wash.
• An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins.
• Assembly dynamics of Mycobacterium tuberculosis FtsZ.
• Audio-visual aids for use by community nutritionists.
• Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function.
• Characterization of Deltoid, a chimeric protein containing the oligomerization site of hepatitis delta antigen.
• Chy-3 mice are Vegfc haploinsufficient and exhibit defective dermal superficial to deep lymphatic transition and dermal lymphatic hypoplasia.
• Conjugated linoleic acid isomers and cancer.
• Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl.
• Factitious lithium toxicity secondary to lithium heparin-containing blood tubes.
• FtsZ, a tubulin homologue in prokaryote cell division.
• Genetics of sexual development: a new paradigm.
• Giant cell tumor of the patella encountered during treatment for patellar fracture.
• Growth characteristics of calves fed an intensified milk replacer regimen with additional lactoferrin.
• Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor.
• Item analysis of the psychoneurotic scales on the Minnesota multiphasic personality inventory in experimental semistarvation.
• Lineage specification in neural crest cell pathfinding.
• Mosaic tetrasomy 12p with triplication of 12p detected by array-based comparative genomic hybridization of peripheral blood DNA.
• Neural stem cell implantation extends life in Niemann-Pick C1 mice.
• Non-neurologic complications following surgery for adolescent idiopathic scoliosis.
• Part 1. Automated change detection and characterization in serial MR studies of brain-tumor patients.
• Prediction of vasovagal syncope from heart rate and blood pressure trend and variability: experience in 1,155 patients.
• Psychological significance of physical restraint to mental patients.
• Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
• Reduction in early dislocation rate with large-diameter femoral heads in primary total hip arthroplasty.
• Star Valley, Wyoming: polygamous haven.
• Studies on human subjects receiving highly agenized food materials.
• Summer populations and movements of the cotton rat and other rodents on the Savannah River refuge.
• The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting.
• Visual performance enhancement training: Evidence-based practice?: 487: 9:40 AM-10:10 AM.