The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality.

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Abstract Text:

Amaral,Caio T Fagundes,Rodrigo Guabiraba, Vieira,Adriano L S Souza,Remo C Russo,Milena P B Soares,Mauro M Teixeira,Danielle G Souza, Amaral,Caio T Fagundes,Rodrigo Guabiraba, Vieira,Adriano L S Souza,Remo C Russo,Milena P B Soares,Mauro M Teixeira,Danielle G Souza,Flávio A Amaral,Caio T Fagundes,Rodrigo Guabiraba,Angélica T Vieira,Adriano L S Souza,Remo C Russo,Milena P B Soares,Mauro M Teixeira,Danielle G Souza,

Ischemia and reperfusion (I/R) injury is associated with a systemic inflammatory response, characterized by intense tumor necrosis factor (TNF)-alpha production and TNF-alpha-dependent tissue injury. Macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine that may induce TNF-alpha release and play an important role in innate immune and inflammatory responses. The aim of this work was to assess whether MIF was involved the inflammatory cascade and injury that follows intestinal I/R. To this end, wild-type (WT) and MIF-deficient (MIF(-/-)) mice underwent 60 minutes of ischemia followed by 60 minutes of reperfusion, after which they were culled for the assessment of inflammatory parameters. I/R was accompanied by an increase in circulating levels of MIF and an increase of vascular permeability, hemorrhage, and production of TNF-alpha in the intestine and lungs. The latter parameters were markedly suppressed in reperfused MIF(-/-) mice, and this was associated with decreased lethality (80% in WT versus 20% in MIF(-/-) mice). Interestingly, the reperfusion-associated neutrophil accumulation in the intestine and lungs was similar in WT and MIF(-/-) mice. Leukocytes isolated from lungs of MIF(-/-) mice were less activated, as assessed by their response to zymosan in a luminol-enhanced chemiluminescence assay. In conclusion, our results suggest that MIF plays an important role in the cascade of events leading to TNF-alpha production and reperfusion-induced tissue injury and lethality in mice.

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Publishing Authors By Initials

FA Amaral,CT Fagundes,R Guabiraba,AT Vieira,AL Souza,RC Russo,MP Soares,MM Teixeira,DG Souza,FA Amaral,CT Fagundes,R Guabiraba,AT Vieira,AL Souza,RC Russo,MP Soares,MM Teixeira,DG Souza,FA Amaral,CT Fagundes,R Guabiraba,AT Vieira,AL Souza,RC Russo,MP Soares,MM Teixeira,DG Souza,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of pathology

VOLUME: 171

Page Numbers: 1887-93

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 30

MONTH: 11

YEAR: 2007

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality.

AFFILIATION: Departmento de Bioquímica e Imunologia, ICB, UFMG, Avenida Antônio Carlos, 6627, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil. mmtex@icb.ufmg.br.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality Related Publications

• A Programmable System of Functional Electrical Stimulation (FES).
• A typical presentation of cutaneous leishmaniasis after renal transplantation.
• Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells.
• All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells.
• Assessment of Acute Skin Irritation in Rabbits using Electrical Impedance Model.
• Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T).
• Dimensional crossover in the purple bronze Li0.9Mo6O17.
• Granular fingers on jammed systems: new fluidlike patterns arising in grain-grain invasion experiments.
• In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway.
• Inhibition of rats extramedullary liver erytropoiesis by hyperbaric oxygen therapy.
• Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis.
• Naturally occurring compounds affect glutamatergic neurotransmission in rat brain.
• Novel cyclopalladated and coordination palladium and platinum complexes derived from alpha-diphenyl ethanedione bis(thiosemicarbazones): structural studies and cytotoxic activity against human A2780 and A2780cisR carcinoma cell lines.
• Proposal of a guanine-based purinergic system in the mammalian central nervous system.
• Quinolinic Acid-induced Seizures Stimulate Glutamate Uptake into Synaptic Vesicles from Rat Brain: Effects Prevented by Guanine-based Purines.
• Silicoproteinosis: high-resolution CT findings in 13 patients.
• Simplified Distributed-Parameter model of Brachial-Radial Arteries for Noninvasive Determination of Mechanical Characteristics of Vessel.
• Temporal envelope changes of compression and speech rate: combined effects on recognition for older adults.
• Ternary complex formation between AmtB, GlnZ and the nitrogenase regulatory enzyme DraG reveals a novel facet of nitrogen regulation in bacteria.
• The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality.
• Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis.
• [Clinical and morphometric evaluations of the angiogenic capacity of chitosan membrane in rabbit corneas]
• [Comparative study of several sinusitis experimental modelling techniques in rabbits.]
• [Impact on tuberculosis incidence rates of removal of repeat notification records.]
• [Mortality trends due to tuberculosis in Brazil, 1980-2004.]
• [Ophthalmologic conditions of AIDS patients with long-term follow-up]
• [Psychotic syndrome developing into dementia as a clinical manifestation of mitochondrial DNA deletion]
• [Surgical removal of a posttraumatic intracardiac foreign body in a child.]
• [Transient diabetes mellitus related to L-asparaginase therapy]
• [Tuberculosis incidence and cure rates, Brazil, 2000-2004.]