The role of lung function in brain tissue oxygenation following traumatic brain injury.

The role of lung function in brain tissue oxygenation following traumatic brain injury. Research Abstract Details 

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The role of lung function in brain tissue oxygenation following traumatic brain injury. Abstract Text:

Guy Rosenthal,J Claude Hemphill,Marco Sorani,Christine Martin,Diane Morabito,Michele Meeker,Vincent Wang,Geoffrey T Manley,Guy Rosenthal,J Claude Hemphill,Marco Sorani,Christine Martin,Diane Morabito,Michele Meeker,Vincent Wang,Geoffrey T Manley,Guy Rosenthal,J Claude Hemphill,Marco Sorani,Christine Martin,Diane Morabito,Michele Meeker,Vincent Wang,Geoffrey T Manley,

Object Previous studies have demonstrated that periods of low brain tissue oxygen tension (PbtO(2)) are associated with poor outcome after head trauma but have primarily focused on cerebral and hemodynamic factors as causes of low PbtO(2). The purpose of this study was to investigate the influence of lung function on PbtO(2) with an oxygen challenge (increase in fraction of inspired oxygen [FiO(2)] concentration to 1.0). Methods This prospective observational cohort study was performed in the neurointensive care unit of the Level 1 trauma center at San Francisco General Hospital. Thirty-seven patients with severe traumatic brain injury (TBI) undergoing brain tissue oxygen monitoring as part of regular care underwent an oxygen challenge, consisting of an increase in FiO(2) concentration from baseline to 1.0 for 20 minutes. Partial pressure of arterial oxygen (PaO(2)), PbtO(2), and the ratio of PaO(2) to FiO(2) (the PF ratio) were determined before and after oxygen challenge. Results Patients with higher PF ratios achieved greater PbtO(2) during oxygen challenge than those with a low PF ratio because they achieved a higher PaO(2) after an oxygen challenge. Lung function, specifically the PF ratio, is a major determinant of the maximal PbtO(2) attained during an oxygen challenge. Conclusions Given that patients with TBI are at risk for pulmonary complications such as pneumonia, severe atelectasis, and adult respiratory distress syndrome, lung function must be considered when interpreting brain tissue oxygenation.

The role of lung function in brain tissue oxygenation following traumatic brain injury. Publishing Authors By Initials

G Rosenthal,JC Hemphill,M Sorani,C Martin,D Morabito,M Meeker,V Wang,GT Manley,G Rosenthal,JC Hemphill,M Sorani,C Martin,D Morabito,M Meeker,V Wang,GT Manley,G Rosenthal,JC Hemphill,M Sorani,C Martin,D Morabito,M Meeker,V Wang,GT Manley,

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The role of lung function in brain tissue oxygenation following traumatic brain injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neurosurgery

VOLUME: 108

Page Numbers: 59-65

Journal Abbreviation: J. Neurosurg.

ISSN: 0022-3085

DAY: 4

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: 1 Departments of Neurosurgery and, 2 Neurology, and, 3 the Program in Biological and Medical Informatics, University of California, San Francisco, California.

Country: United States

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MEDLINETA: J Neurosurg

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