The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes.

The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes. Research Abstract Details 

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The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes. Abstract Text:

Xiaoyan Liang,Linlin Ma,Ngoc L Thai,John J Fung,Shiguang Qian,Lina Lu,

Development of type 1 diabetes has been attributed to T-cell-mediated autoimmunity, which is regulated by antigen-presenting cells. To study the role of liver-derived B220(+) regulatory dendritic cells (DCs) in the development of diabetes in non-obese diabetic (NOD) mice, we found that liver 220(+) DCs could easily be propagated from young NOD mice, but that such propagation was extremely difficult from mice older than 11 weeks, when insulitis began. This was not simply an age-related phenomenon, because liver B220(+) DCs were readily propagated from both young and old congenic non-obese diabetic-resistant (NOR) and normal BALB/c mice. It was therefore speculated that the development of diabetes might be associated with a lack of precursors of B220(+) DC in the liver in this animal model. Unfortunately, the specific marker for precursors of liver B220(+) DC has not been identified. An alternative approach to supplement liver B220(+) DCs by intravenous administration significantly inhibited the development of diabetes by inducing T-cell hyporesponsiveness via enhancement of their apoptotic death. Liver B220(+) DCs were capable of effectively presenting antigens but, unlike plasmacytoid DCs, did not express CD11c and were not interferon-alpha producers. These observations may throw new light on the aetiopathology of type 1 diabetes.

The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes. Publishing Authors By Initials

X Liang,L Ma,NL Thai,JJ Fung,S Qian,L Lu,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunology

VOLUME: 120

Page Numbers: 251-60

Journal Abbreviation: Immunology

ISSN: 0019-2805

DAY: 3

MONTH: Feb

YEAR: 2007

The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes. Information

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LANGUAGE: eng

NlmUniqueID: 374672

The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

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Grant and Affiliation Information for The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes.

AFFILIATION: Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Country: England

AGENCY: United States NIDDK

GRANT: DK058316

ACRONYM: DK

MEDLINETA: Immunology

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