The Role of Intracellular Calcium and RhoA in Neuronal Migration.

The Role of Intracellular Calcium and RhoA in Neuronal Migration. Research Abstract Details 

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The Role of Intracellular Calcium and RhoA in Neuronal Migration. Abstract Text:

Clare H Faux,John G Parnavelas,Clare H Faux,John G Parnavelas,Clare H Faux,John G Parnavelas,Clare H Faux,John G Parnavelas,

The successive steps involved in cell migration include extension of the leading process, followed by translocation of the soma and retraction of the trailing process. These events require the coordinated activity of various intracellular signaling mechanisms. Recent evidence suggests that the intracellular distribution of calcium ions and of the Rho guanosine triphosphatase (RhoGTPase), RhoA, are important components of these mechanisms. During migration, the growth cone of the leading process senses guidance cues present in the extracellular environment. These cues, acting through appropriate receptors on the growth cone, induce changes in the concentration of calcium, both in the growth cone and in the soma. These changes in the distribution of calcium cause a redistribution of intracellular RhoA and the eventual translocation of the soma. The trailing process is retracted as the cell moves forward.

The Role of Intracellular Calcium and RhoA in Neuronal Migration. Publishing Authors By Initials

CH Faux,JG Parnavelas,CH Faux,JG Parnavelas,CH Faux,JG Parnavelas,CH Faux,JG Parnavelas,

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The Role of Intracellular Calcium and RhoA in Neuronal Migration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Science's STKE : signal transduction knowledge env

VOLUME: 2007

Page Numbers: pe62

Journal Abbreviation: Sci. STKE

ISSN: 1525-8882

DAY: 13

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK.

Country: United States

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MEDLINETA: Sci STKE

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